Functional disturbances in brain following injury: search for underlying mechanisms

Neurochemical Research
H M Pappius, L S Wolfe

Abstract

It was shown previously that local cerebral glucose utilization is less than 50% of normal in all cortical areas of rat brain 3 days following a focal freeze-lesion and that this effect of trauma is significantly diminished by dexamethasone (0.25 mg/Kg/day), and by indomethacin (7.5 mg/Kg single dose). To elucidate the mechanism of action of steroids and non-steroidal antiinflammatory drugs in traumatized brain, the effects of dexamethasone and indomethacin on arachidonic acid release, malondialdehyde production and prostaglandin synthesis in the lesion area were investigated. Five seconds after a freezing lesion arachidonic acid was significantly increased in the lesion area of untreated animals. Neither dexamethasone nor indomethacin had any effect on this release. The thiobarbituric acid reaction, as an estimate of malondialdehyde and non-enzymatic free radical lipoperoxide formation from unsaturated free fatty acids showed no change in the control and lesion areas of untreated and both dexamethasone and indomethacin treated groups. There was a marked increase in PGF2 alpha, PGE2, PGD2 in the lesion area of untreated animals. Indomethacin prevented the formation of prostaglandins by more than 90% while dexamethasone had no e...Continue Reading

References

Jan 1, 1979·Annual Review of Neuroscience·B S McEwenD W Pfaff
Feb 1, 1978·Journal of Neurosurgery·P A Tornheim, R L McLaurin
Jul 1, 1976·Canadian Journal of Biochemistry·L S WolfeH M Pappius
Apr 1, 1976·Biochemical Medicine·K Yagi
Feb 1, 1969·Archives of Neurology·H M Pappius, W P McCann
Feb 1, 1981·Archives of Biochemistry and Biophysics·T ShimizuO Hayaishi

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Citations

Jan 1, 1986·Acta Neuropathologica·P J LuthertO E Pratt
Sep 1, 1991·Neurochemical Research·H M Pappius
Jan 1, 1986·Agents and Actions·M KoltaiL Szekeres
Aug 1, 1987·Neurochemical Pathology·R Saunders, L A Horrocks
Jan 1, 1992·Journal of Neuroscience Methods·P A StewartE Hayakawa
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·H M Pappius
Mar 1, 1995·Free Radical Biology & Medicine·D Liu, L Li
Jun 1, 1997·Surgical Neurology·D AwasthiW A Pryor
Nov 24, 2001·Brain Research. Developmental Brain Research·T D Schmanke, J R Villablanca
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P DemediukL A Horrocks
Oct 1, 1996·Journal of Clinical and Experimental Neuropsychology·T A NovackW T Jackson
Apr 16, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P MorleyD B Stanimirovic
Apr 1, 1989·Journal of Neurosurgery·A BaethmannO Kempski
Jul 1, 1990·Journal of Neurochemistry·T Shimizu, L S Wolfe
Jul 1, 1987·Journal of Neurochemistry·H M Pappius, R Dadoun
Sep 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D P ArcherH M Pappius
Mar 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M InoueH M Pappius
Dec 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H M Pappius, L S Wolfe
Apr 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F R DomerL Sokoloff
Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M BuczekH M Pappius
Jan 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J A Yergey, M P Heyes
Jun 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H M PappiusM McHugh
Oct 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M WahlL Schilling
May 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F TegtmeierM Höller
May 1, 1985·Stroke; a Journal of Cerebral Circulation·A TósakiL Szekeres
Mar 1, 1988·Stroke; a Journal of Cerebral Circulation·B KatzM D Mitchell
Sep 15, 2007·Neuropathology and Applied Neurobiology·V A AgostonE Madarász
Jan 1, 1985·Central Nervous System Trauma : Journal of the American Paralysis Association·H M Pappius
Nov 1, 1984·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J J RaymondS Nag
Nov 15, 1983·Biochemical and Biophysical Research Communications·H KoenigC Y Lu

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