Functional Diversity of Human Dendritic Cells

Advances in Experimental Medicine and Biology
Eynav Klechevsky

Abstract

At the crossroad between innate and adaptive immunity are the dendritic Cells (DCs), a "novel cell type." discovered in 1973 by Ralph Steinman. Although not entirely appreciated at first, it is clear that they play a critical role as specialized antigen-presenting cells and essential mediators in shaping immune reactivity and tolerance. Dendritic cells are now recognized as a heterogeneous group of cells in terms of cell-surface markers, anatomic location, and function adapted to protect against an array of pathogens and conditions. Importantly, these subsets are also unique to each species. While significant progress has been made on the identification and function of mouse DC subsets, much less is known about human cells. Here we review the fascinating biology of human skin DCs and describe tolerogenic principles that are critical in maintaining immune homeostasis and for controlling inflammation, as well as mechanisms that are fundamental to confer immunity. We surmise that these principles could be applied to DCs across organs, and could be harnessed for the treatment of various human autoimmune, inflammatory diseases, as well as cancer. Importantly, to leverage the relevance of basic research to the clinical setting, it is...Continue Reading

Citations

Jul 14, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laurent GorvelEynav Klechevsky
Apr 5, 2019·Oncology Letters·Monica NeaguSabina Zurac
Jul 9, 2016·The British Journal of Ophthalmology·Adam WilkinsonNick Di Girolamo
Nov 21, 2019·Nature Immunology·Ioanna E GalaniEvangelos Andreakos
Aug 2, 2019·Clinical Microbiology Reviews·Juarez Antonio Simões Quaresma
Nov 24, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Bui Viet AnhHoang Thi My Nhung
Jun 14, 2018·Cancer Immunology Research·Christiane QuerfeldJames W Young
Sep 14, 2021·Frontiers in Immunology·Aislyn OuleeRobert L Modlin
Oct 17, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel KorenfeldEynav Klechevsky

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