Functional domains of the Drosophila melanogaster muscle myosin heavy-chain gene are encoded by alternatively spliced exons.

Molecular and Cellular Biology
E L GeorgeC P Emerson

Abstract

The single-copy Drosophila muscle myosin heavy-chain (MHC) gene, located at 36B(2L), has a complex exon structure that produces a diversity of larval and adult muscle MHC isoforms through regulated alternative RNA splicing. Genomic and cDNA sequence analyses revealed that this 21-kilobase MHC gene encodes these MHC isoforms in 19 exons. However, five sets of these exons, encoding portions of the S1 head and the hinge domains of the MHC protein, are tandemly repeated as two, three, four, or five divergent copies, which are individually spliced into RNA transcripts. RNA hybridization studies with exon-specific probes showed that at least 10 of the 480 possible MHC isoforms that could arise by alternative RNA splicing of these exons are expressed as MHC transcripts and that the expression of specific members of alternative exon sets is regulated, both in stage and in muscle-type specificity. This regulated expression of specific exons is of particular interest because the alternatively spliced exon sets encode discrete domains of the MHC protein that likely contribute to the specialized contractile activities of different Drosophila muscle types. The alternative exon structure of the Drosophila MHC gene and the single-copy nature ...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D M MillerJ Karn
Aug 6, 1987·Nature·Y Y ToyoshimaJ A Spudich
Mar 22, 1985·Science·D J Lipman, W R Pearson
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K MogamiC P Emerson
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C E Rozek, N Davidson
Jun 1, 1986·Molecular and Cellular Biology·C C Karlik, E A Fyrberg
Jan 1, 1987·Annual Review of Biochemistry·C P Emerson, S I Bernstein
Jan 1, 1987·Annual Review of Cell Biology·H M Warrick, J A Spudich
Feb 13, 1987·Science·P A Sharp
Nov 17, 1986·European Journal of Biochemistry·E J MitchellJ Kendrick-Jones
Jan 1, 1967·Progress in Biophysics and Molecular Biology·J W Pringle
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Aviv, P Leder
Apr 1, 1984·Developmental Biology·G S Butler-Browne, R G Whalen
Feb 1, 1980·Cell·E A FyrbergK L Kindle
Oct 22, 1982·Science·G M Rubin, A C Spradling
Mar 25, 1983·Nucleic Acids Research·L DenteR Cortese
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L A LeinwandB Nadal-Ginard
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M Church, W Gilbert
Sep 2, 1983·Science·A I CaplanH M Eppenberger
Jan 1, 1984·Annual Review of Biophysics and Bioengineering·A D McLachlan
Jan 1, 1984·Annual Review of Biochemistry·W F Harrington, M E Rodgers

❮ Previous
Next ❯

Citations

Jul 27, 2002·Annual Review of Cell and Developmental Biology·Kathleen A ClarkCarol C Gregorio
Sep 13, 2011·Nucleic Acids Research·Julian P VenablesFrançois Juge
Jan 10, 1997·Journal of Molecular Biology·D M StandifordC P Emerson
Aug 21, 2003·Journal of Molecular Biology·Erzsébet PolyákClara Franzini-Armstrong
Sep 13, 2005·Journal of Molecular Biology·Becky M MillerSanford I Bernstein
Mar 9, 2006·Izvestiia Akademii nauk. Seriia biologicheskaia·N S Miuge, N D Ozerniuk
Dec 1, 1992·Developmental Biology·H F Epstein, S I Bernstein
Dec 1, 1992·Developmental Biology·E Bandman
Oct 1, 1991·Journal of Molecular Evolution·A F StewartR Zak
Mar 1, 2006·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Shugo Watabe, Daisuke Ikeda
Jan 1, 1989·Cell Motility and the Cytoskeleton·E Fyrberg
Jul 25, 2006·Genomics·Kati DonnerCarina Wallgren-Pettersson
Sep 25, 2003·The Journal of Biological Chemistry·Becky M MillerMichael A Geeves
Feb 10, 2018·Wiley Interdisciplinary Reviews. RNA·Yongfeng JinLina Bian
Mar 20, 2002·Nature Cell Biology·Douglas M SwankSanford I Bernstein
Nov 1, 1994·Plant Molecular Biology·M KinkemaJ Schiefelbein
Oct 1, 1995·The Journal of Experimental Zoology·N S Morgan
Dec 15, 1993·The Journal of Experimental Zoology·J L Cotton, D L Mykles
Jul 1, 2005·Physiological Reviews·Scott L Hooper, Jeffrey B Thuma
Jan 11, 2011·Nature Structural & Molecular Biology·Yun YangYongfeng Jin
Dec 13, 2002·American Journal of Physiology. Cell Physiology·Kimberly Palmiter LittlefieldSanford I Bernstein
Mar 15, 2014·The Journal of Biological Chemistry·William A KronertSanford I Bernstein
Mar 31, 2004·The Journal of Cell Biology·Enrico S Montana, J Troy Littleton
Feb 28, 2003·The Journal of Biological Chemistry·Douglas M SwankSanford I Bernstein
Aug 1, 1991·Journal of Muscle Research and Cell Motility·J O VigoreauxM L Pardue
Feb 1, 1996·Journal of Muscle Research and Cell Motility·J R SellersF Wang
Nov 21, 2015·The Journal of Biological Chemistry·Marieke J BloeminkMichael A Geeves

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.