Functional dysconnectivity within the emotion-regulating system is associated with affective symptoms in major depressive disorder: A resting-state fMRI study

The Australian and New Zealand Journal of Psychiatry
Zongling HeHuafu Chen

Abstract

Major depressive disorder (MDD) can be characterized as a multidimensional and system-level disorder. The neuropathophysiological abnormalities have been reported to be distributed in emotion regulation system, involving the prefrontal cortex (PFC), limbic and striatum in convergent studies. Decrease of positive affect and increase of negative affect are recognized as a hallmark of MDD. However, the dysfunctions in affective processing in MDD within the emotion regulation system remains largely unclear. In this study, our goals are to characterize the dysconnectivity pattern within this system and explore the relationships between this kind of dysconnectivity pattern and affective symptoms, which might help us better look into the neuropathophysiological mechanisms underlying MDD. A total of 34 MDD and 34 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rsfMRI). The alterations in functional connectivity (FC) within the emotion regulation system and their relationships with affective symptoms were explored. Compared with HCs, MDD patients showed aberrant FC within this system. Importantly, deceased FC was mainly involved in the prefrontal-limbic system, while elevated FC was observed in the ...Continue Reading

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Dec 1, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zongling HeHuafu Chen

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Citations

Nov 6, 2020·Human Brain Mapping·Amir EbneabbasiMasoud Tahmasian
Apr 27, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zongling HeHuafu Chen

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Software Mentioned

AlphaSim
SPM12
REST

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