Functional dyspepsia is associated with cagA-positive Helicobacter pylori strains

Scandinavian Journal of Gastroenterology
R J LoffeldE J Kuipers

Abstract

The antigen CagA can be used as a marker for virulence of Helicobacter pylori. It is tempting to assume that H. pylori strains positive for cytotoxin-associated gene A (cagA) could be responsible for functional dyspepsia. A cross-sectional study was performed in patients presenting with functional dyspepsia to correlate the clinical presentation with the presence of cagA-positive and -negative H. pylori strains. Consecutive patients referred for endoscopy were studied. An inclusion criterion was the absence of any endoscopic abnormality. Biopsy specimens were obtained from the gastric antrum for HE and immunoperoxidase stain, rapid urease test, and culture. A serum sample was taken for detection of IgG antibodies against H. pylori as well as CagA. A validated questionnaire of 14 questions regarding the upper gastrointestinal tract was used for assessment of the clinical presentation. Nine questions were scored on a 5-point Likert scale. 422 patients were included, 222 were H. pylori-positive, the remaining 200 were H. pylori-negative. Mean symptom score in patients with cagA-positive strains was significantly higher than in patients with cagA-negative strains. No difference was present if cagA-negative patients were compared wi...Continue Reading

Citations

Jan 16, 2004·Alimentary Pharmacology & Therapeutics·G TreiberP Malfertheiner
Apr 20, 2002·Journal of Pediatric Gastroenterology and Nutrition·Judy B Splawski
Feb 19, 2002·Alimentary Pharmacology & Therapeutics·N J Talley, C Quan
May 19, 2006·Journal of Gastroenterology and Hepatology·Ernst J Kuipers
Nov 1, 2002·Scandinavian Journal of Gastroenterology. Supplement·R J L F Loffeld, R W M van der Hulst
Aug 26, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Aya Aly AshrafHeba Mohamed Shawky

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