PMID: 7518295Apr 1, 1994Paper

Functional effects and ligand binding of chimeric galanin-neuropeptide Y (NPY) peptides on NPY and galanin receptor types

British Journal of Pharmacology
U KahlL Grundemar

Abstract

1. The effects and binding characteristics of a series of chimeric galanin-neuropeptide Y (NPY) peptides were examined in various preparations known to contain a predominant population of either Y1 or Y2 receptors for NPY or galanin receptors. 2. NPY suppressed the electrically stimulated twitches of the rat vas deferens (Y2 receptors), while galanin enhanced the electrically stimulated twitches. The galanin-NPY peptides M 32 (galanin(1-13)-NPY(25-36)), M69A (galanin(1-13)-Lys-[epsilon NH-Gly-NPY(4-1)]NPY(25-36)) and M88 (galanin(1-12)-Ala-NPY(25-36)) evoked a concentration-dependent suppression of the electrically stimulated twitches. These chimeric peptides were about equipotent with NPY, while NPY (13-36) was about five times less potent than NPY itself. Also a stochiometric combination of the N- and C-terminal fragments NPY (1-24)NH2 and NPY (25-36) (each at 1 microM) was inactive in vas deferens. M120 (galanin (1-13)-NPY(14-36) (1 microM) did not affect the NPY-mediated suppression of the stimulated twitches. 3. NPY evoked a concentration-dependent contraction in the guinea-pig isolated caval vein (Y1 receptors), while galanin (< or = 1 microM) was inactive. M32, M69A and M88 induced a slight contraction at very high conce...Continue Reading

References

Jan 1, 1992·British Journal of Pharmacology·L GrundemarR Håkanson
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Citations

Nov 5, 1998·Regulatory Peptides·P SharmaD Larhammar
Feb 14, 2002·Chemistry & Biology·Michelle FarquharJohn Howl
Mar 12, 1998·The Journal of Peptide Research : Official Journal of the American Peptide Society·M PoogaU Langel
Apr 3, 1999·Neuropeptides·E Karelson, U Langel

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