PMID: 7518601Apr 14, 1994Paper

Functional effects of a family of galanin antagonists on the cardiovascular system in anaesthetised cats

Regulatory Peptides
L G UlmanD I McCloskey

Abstract

Previous studies have shown that injection of galanin (GAL: 6.2 nmol/kg) causes prolonged inhibition of cardiac vagal action in anaesthetised cats. Stimulation of the cardiac sympathetic nerve (16 Hz for 5 min) also produces inhibition of cardiac vagal action, an effect which has been proposed to be due to the release of endogenous GAL from sympathetic nerves. In a previous study we tested galantide (M15) and in this study we compared galantide with two other GAL antagonists for their GAL antagonist activity in our experimental model. Each of these incorporate the N-terminal fragment GAL 1-13 and a C-terminal portion of another bioactive peptide and all are C-terminally amidated. GAL 1-13 Substance P 5-11 amide (galantide: M15: 62 nmol/kg and 156 nmol/kg), GAL 1-13 Spantide amide (C7: 156 nmol/kg) and GAL 1-13 NPY 24-36 amide (M32a: 62 nmol/kg) all significantly reduced the cardiac vagal inhibitory effect of exogenous GAL and also reduced the effect of sympathetic stimulation on subsequent cardiac vagal slowing, giving strong support to our hypothesis that GAL is involved in this phenomenon. No antagonist reduced the depressor effect of GAL. This study demonstrates the GAL antagonist properties of these agents on autonomic neur...Continue Reading

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Z Wiesenfeld-HallinT Bartfai
Aug 1, 1992·Trends in Pharmacological Sciences·T BartfaiU Langel
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T BartfaiS Nilsson
Jan 15, 1993·Brain Research·J N CrawleyT Bartfai

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Citations

Dec 1, 1995·Cellular and Molecular Neurobiology·K KaskT Bartfai
Nov 14, 2007·Journal of Molecular Neuroscience : MN·Sabine M SchmidhuberSusan D Brain
Sep 22, 1995·Regulatory Peptides·J N Crawley
Apr 3, 1999·Journal of the Autonomic Nervous System·M A Smith-WhiteE K Potter
Feb 3, 1999·Annals of the New York Academy of Sciences·D WynickV Pachnis
Feb 3, 1999·Annals of the New York Academy of Sciences·E Potter
Oct 7, 2006·The Journal of Investigative Dermatology·Sabine M SchmidhuberSusan D Brain

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