PMID: 8584499Aug 1, 1995Paper

Functional effects of adrenochrome in isolated rabbit heart

Pharmacology & Toxicology
A F Rump, W Klaus

Abstract

The cardiotoxic effects of catecholamines have been explained in part by the generation of oxygen free radicals and aminochromes. The role of aminochromes remains however controversial. It has previously been demonstrated that adrenochrome, an oxidation product of adrenaline, shows cardiotoxic properties only at very high concentrations, and it has been suggested that the deleterious effects observed may be caused by a worsening in myocardial perfusion. The functional properties of adrenochrome were examined in isolated spontaneously-beating rabbit hearts with depleted catecholamine stores (reserpin 7.0 mg/kg 16-24 hr before preparation, Langendorff, constant pressure: 70 cm H2O, Tyrode solution, [Ca++]sol. 1.8 mmol/l, 37 degrees). Cumulative concentration-response curves show an adrenochrome-concentration-dependent increase of contractility (left ventricular pressure, EC50 = 3.6 x 10(-6) M; +dp/dtmax, EC50 = 1.6 x 10(-5) M), whereas myocardial relaxation was impaired (-dp/dtmax, EC50 = 2.6 x 10(-5) M; -dp/dtmax/+dp/dtmax = 0.68 at 10(-4) M). Heart-rate was only slightly enhanced (+10% at 10(-4) M), and the coronary flow was markedly influenced only by adrenochrome 10(-4) M (-17%). The relative coronary flow (= global coronary ...Continue Reading

References

Oct 1, 1979·Clinical Cardiology·D BallerG Hellige
Jan 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·G RichardtA Schömig
Jul 1, 1989·Toxicology Letters·A BindoliL Galzigna
May 4, 1989·Molecular and Cellular Biochemistry·K S DhallaN S Dhalla
Apr 1, 1985·Journal of Molecular and Cellular Cardiology·S B MatthewsA K Campbell
Mar 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·A F Rump, W Klaus
Feb 1, 1993·Anesthesia and Analgesia·A F RumpW Klaus

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Citations

Aug 27, 2013·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Chris Salisbury

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