Functional effects of castration on alpha1-adrenoceptors in rat vas deferens

European Journal of Pharmacology
André S Pupo

Abstract

The effects of castration on alpha1-adrenoceptors in rat vas deferens were investigated by determining the actions of selective antagonists against the contractions induced by noradrenaline. The results obtained in vas deferens from control rats suggest participation of alpha1A-adrenoceptors as judged by the pA2 values for prazosin (9.6), benoxathian (9.5), 2(2,6-dimethoxyphenoxyethyl) amino-methyl-1,4-benzodioxone hydrochloride) (WB 4101) (9.6), phentolamine (8.4), 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5] decane-7,9-dionedihydrochloride (BMY 7378) (6.7) and by the insensitivity to chloroethylclonidine (100 microM, 45 min). In vas deferens from castrated rats, WB 4101 and spiperone showed slopes lower than 1.0 in the Schild plots, suggesting participation of multiple receptors. In these organs, noradrenaline contractions were partially inhibited by chloroethylclonidine (100 microM, 45 min), indicating participation of alpha1B-adrenoceptors. After chloroethylclonidine treatment, WB 4101 showed a slope not different from 1.0 in the Schild plot, resulting in a pA2 of 9.4, which indicates an interaction with alpha1A-adrenoceptors. It is suggested that castration modifies the functional alpha1-adrenoceptors sub...Continue Reading

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Citations

Mar 21, 2008·Cell and Tissue Research·Daniel Barboza Cava QueirózMaria Christina W Avellar
May 17, 2005·Life Sciences·Oduvaldo Câmara Marques Pereira, Renata Carolina Piffer
Jun 24, 2003·European Journal of Pharmacology·Marcelo CamposAndré S Pupo
Nov 11, 1999·European Journal of Pharmacology·M A SilvaC S Porto
May 17, 2014·Life Sciences·Guilherme Henrique Souza BomfimNeide Hyppolito Jurkiewicz
Nov 19, 2015·The American Journal of Drug and Alcohol Abuse·Guilherme Henrique Souza BomfimNeide Hyppolito Jurkiewicz
Aug 26, 2009·Life Sciences·Lidyane R G CastorOduvaldo C M Pereira
Jul 9, 2004·Life Sciences·Fúlvio R MendesMaria Christina W Avellar
Jan 27, 2011·Biochemical Society Transactions·Hans-Joachim Gabius
Jan 24, 2002·Biology of Reproduction·Daniel B C QueirózMaria Christina W Avellar
Sep 2, 2009·Anais Da Academia Brasileira De Ciências·Maria Christina W AvellarCatarina S Porto
Oct 25, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M CamposA S Pupo
Aug 2, 2002·International Journal of Impotence Research·E S Hayes, P G Adaikan
Feb 8, 2019·The Journal of Pharmacology and Experimental Therapeutics·Andre MuellerAndré S Pupo
Apr 25, 2018·The Journal of Pharmacology and Experimental Therapeutics·Enio S A PaciniLuiz R A Kiguti
Sep 22, 2015·Life Sciences·Neide Hyppolito JurkiewiczMaria Christina Werneck Avellar
Jun 2, 2009·Toxicology and Applied Pharmacology·Fernanda D NojimotoAndré S Pupo

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