Functional effects of variants of the RNA chaperone Hfq

Biochemical and Biophysical Research Communications
Elisabeth SonnleitnerUdo Bläsi

Abstract

The ring-shaped RNA chaperone Hfq has recently received much attention owing to its multiple roles in RNA metabolism. In this study we have performed a mutational analysis of the Escherichia coli hfq gene, and have studied the effects of amino acid substitutions at several positions in the Hfq protein as well as of C-terminal truncations on its role in phage Qbeta replication, in repression of a target mRNA, and on the stability of the small regulatory RNA DsrA. These functional studies provided insights into the interaction of Hfq with RNA and suggested a role for the C-terminus of Hfq in DsrA stability.

References

Apr 1, 1986·Molecular & General Genetics : MGG·S Lin-Chao, H Bremer
Jan 11, 1988·Nucleic Acids Research·R E Rose
Aug 10, 1968·Nature·M T Franze de FernandezJ T August
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·E HajnsdorfP Régnier
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·E Hajnsdorf, P Régnier
Feb 27, 2001·Journal of Bacteriology·D D SledjeskiA Zhang
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·T AchselR Lührmann
Jul 11, 2001·Genes & Development·K M WassarmanS Gottesman
Jan 24, 2002·Molecular Cell·Aixia ZhangGisela Storz
Jan 24, 2002·Molecular Cell·Thorleif MøllerPoul Valentin-Hansen
Feb 28, 2002·The EMBO Journal·Zhongwei LiMurray P Deutscher
Jul 4, 2002·Journal of Molecular Biology·Véronique ArluisonPhilippe Régnier
Jul 9, 2002·Genes & Development·Thorleif MøllerPoul Valentin-Hansen
Aug 10, 2002·Journal of Bacteriology·Sidney R Kushner
Mar 14, 2003·EMBO Reports·Isabella MollUdo Bläsi
Jul 11, 2003·Nucleic Acids Research·Claude SauterDietrich Suck
Nov 19, 2003·Molecular Microbiology·Aixia ZhangSusan Gottesman
Jan 24, 2004·The EMBO Journal·Thomas A Geissmann, Danièle Touati
Mar 11, 2004·Molecular Microbiology·Poul Valentin-HansenChristina Udesen
Mar 20, 2004·European Journal of Biochemistry·Véronique ArluisonPhilippe Regnier

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Citations

Nov 15, 2007·Nucleic Acids Research·Branislav VecerekUdo Bläsi
Nov 28, 2009·Nucleic Acids Research·Jesper Sejrup NielsenBirgitte Haahr Kallipolitis
Feb 19, 2011·Nucleic Acids Research·Mads Beich-FrandsenKristina Djinovic-Carugo
Jun 30, 2009·Journal of Bacteriology·Dominik Schilling, Ulrike Gerischer
Oct 24, 2007·BMC Molecular Biology·Marion ScheibeMario Mörl
Aug 24, 2007·PLoS Biology·Erel LevineTerence Hwa
May 11, 2013·International Journal of Medical Microbiology : IJMM·Chee-Hock HoeThean-Hock Tang
Mar 1, 2012·Biochimie·Eliane Hajnsdorf, Irina V Boni
Sep 6, 2011·Biochimica Et Biophysica Acta·Taylor B Updegrove, Roger M Wartell
Oct 5, 2010·Journal of Molecular Biology·Anders Steno OlsenPoul Valentin-Hansen
Mar 31, 2007·Current Opinion in Microbiology·Richard G Brennan, Todd M Link
Aug 15, 2015·Protein Science : a Publication of the Protein Society·Catherine VrentasStephen H Leppla
Mar 8, 2013·RNA Biology·E Gerhart H Wagner
Apr 11, 2018·Wiley Interdisciplinary Reviews. RNA·Andrew Santiago-Frangos, Sarah A Woodson
Aug 23, 2017·ELife·Andrew Santiago-FrangosSarah A Woodson
Jul 16, 2011·Nature Reviews. Microbiology·Jörg Vogel, Ben F Luisi
Jun 14, 2020·The Journal of Biological Chemistry·Josh McQuailSivaramesh Wigneshweraraj
Dec 24, 2018·Nature Communications·Hsin-Ho HuangDomitilla Del Vecchio
Sep 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Andrew Santiago-FrangosSarah A Woodson

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