Functional efficiency of the senescent cells: replace or restore?

Annals of the New York Academy of Sciences
Sang Chul ParkSung Jin Ryu

Abstract

It is generally accepted that aging is a phenomenon of irreversibility, inevitability, and universality with parenchymal loss and functional decline. Consequently, the major goals of aging research are focused on the development of a replace strategy of the aged organs or cells, based on immortalizing tools, stem cells, or artificial substitutes. Recently, however, a new concept of functional recovery has been introduced on the basis of the functional restoration of the responsiveness of the senescent cells toward a variety of agonists, including growth factors. The aging phenotypes of hyporesponsiveness and morphological alteration are shown to be readily adjusted by modulation of the several membrane-associated molecules, named gatekeeper molecules, among which caveolin is one of the major determinants. Caveolin is the essential component of the caveolae, responsible for regulation of signal transduction, endocytosis and trancytosis, and cytoskeletal arrangement via its scaffolding domain. The caveolin status is associated strictly with cellular transformation, if depleted, and with senescent phenotype, if overexpressed. Therefore, simple reduction of caveolin status in senescent cells leads to restoration of the functional r...Continue Reading

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Citations

Dec 9, 2008·Antioxidants & Redox Signaling·Hemal H Patel, Paul A Insel
Mar 3, 2011·Cancer·Zhang WeihuaIsaiah J Fidler
Nov 8, 2014·British Journal of Pharmacology·Jan M SchillingHemal H Patel
Dec 22, 2004·Mechanisms of Ageing and Development·Kyung A Cho, Sang Chul Park
Jun 3, 2017·Experimental & Molecular Medicine·Sang Chul Park
May 6, 2006·Journal of Cellular Biochemistry·Yoon Sin OhSang Chul Park

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