Functional epileptic network in left mesial temporal lobe epilepsy detected using resting fMRI.

Epilepsy Research
Victoria L MorganBassel Abou-Khalil

Abstract

The purpose of this study was to determine transient functional signal activity in a small, homogeneous group of left temporal lobe epilepsy (TLE) patients, without the use of EEG; and to use one of these activated regions to identify a possible epileptogenic network across the whole brain in this group. Resting functional MRI scanning was performed on five left TLE patients who underwent selective amygdalohippocampectomy resulting in seizure control and 10 healthy control subjects. Activation maps of functional signal peaks were calculated using a data-driven analysis, 2dTCA, across the group of patients. In addition to the expected region of activation in the left anterior hippocampus, the results of the 2dTCA analysis revealed activity in the bilateral insular cortex and default-mode network which are not commonly reported using fMRI, but are supported by other electrical and functional changes. The region of activation corresponding to the anterior hippocampal region of resection (presumably the epileptogenic region) was used as a seed region for fMRI functional connectivity analysis. This revealed increased negative connectivity in the patients as compared to controls across a network including thalamic, brainstem, frontal...Continue Reading

References

Sep 30, 1974·JAMA : the Journal of the American Medical Association·P Lazar
Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Sep 14, 2001·Epilepsia·E H BertramJ M Williamson
Mar 29, 2003·Epilepsy & Behavior : E&B·Andrew D. Norden, Hal Blumenfeld
May 6, 2003·Annals of Neurology·Afraim Salek-HaddadiDavid R Fish
Sep 30, 2003·The Journal of Comparative Neurology·Yasushi Kobayashi, David G Amaral
Oct 10, 2003·Brain : a Journal of Neurology·Francine ChassouxFrançois-Xavier Roux
Feb 20, 2004·Magnetic Resonance Imaging·Pallab K Bhattacharyya, Mark J Lowe
Apr 16, 2004·Cerebral Cortex·Hal BlumenfeldSusan S Spencer
Apr 29, 2005·Epilepsia·James X TaoJohn S Ebersole
Sep 24, 2005·Human Brain Mapping·Eliane KobayashiJean Gotman
Oct 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·J GotmanF Dubeau
Nov 30, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Y AghakhaniJ Gotman
Jan 13, 2006·Annals of Neurology·Anthony B WaitesGraeme D Jackson
Jan 19, 2006·Epilepsia·Dominique S RosenbergMichel Magnin
Feb 28, 2006·Epilepsia·Eliane KobayashiJean Gotman
May 2, 2006·Journal of Magnetic Resonance Imaging : JMRI·Jean GotmanFrançois Dubeau
Jun 9, 2006·Brain : a Journal of Neurology·Maxime GuyeFabrice Bartolomei
Feb 10, 2007·Human Brain Mapping·Victoria L MorganJohn C Gore
Jul 25, 2007·Epilepsy Research·Victoria L MorganBassel Abou-Khalil
Aug 8, 2007·Brain : a Journal of Neurology·Donna Rose AddisMary Pat McAndrews
Sep 5, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Giampiero GiovacchiniWilliam H Theodore
Oct 9, 2007·Neuroreport·Kathrin WagnerAndreas Schulze-Bonhage
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Aug 5, 2008·Seizure : the Journal of the British Epilepsy Association·Lars FringsKathrin Wagner
Sep 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dario J EnglotHal Blumenfeld
Jan 14, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Patrick DupontMaurizio Dondi

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Citations

Feb 13, 2013·Brain Topography·Ivan RektorIrena Rektorová
Jun 7, 2012·Brain : a Journal of Neurology·Natalie L VoetsNeda Bernasconi
Aug 2, 2011·Epilepsia·Michiro NegishiR Todd Constable
May 23, 2013·PloS One·Gong-Jun JiGuangming Lu
Apr 2, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Junjing WangRuiwang Huang
May 2, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Craig A Beers, Paolo Federico
Mar 1, 2011·Epilepsy Research·Yasha Borna KhatamianJean Gotman
Feb 10, 2011·Neuroscience Letters·Asht Mangal MishraHal Blumenfeld
Oct 11, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Petros StylianouSagi Harnof
Aug 2, 2014·Human Brain Mapping·Anas Salah EddinMalek Adjouadi
Oct 30, 2012·Epilepsy & Behavior : E&B·Zulfi HaneefJohn M Stern
Mar 23, 2011·NeuroImage·Brendan D KilloryHal Blumenfeld
Sep 16, 2011·Epilepsy Research·Giridhar P KalamangalamPonnada A Narayana
Nov 13, 2014·Frontiers in Neurology·Nahla L FaizoDavid Reutens
Jun 18, 2016·PloS One·Shuyan SongHaibo Xu

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