PMID: 3765351Jun 1, 1986Paper

Functional evaluation of macrophages in fish from a polluted estuary

Veterinary Immunology and Immunopathology
B A Weeks, J E Warinner

Abstract

The chemotactic and phagocytic efficiencies of macrophages from spot, Leiostomus xanthurus and hogchoker, Trinectes maculatus are reported here. Fish were captured from the York and Ware Rivers, two relatively nonpolluted rivers, and from a reach of the Elizabeth River, known to be contaminated with high concentrations of polynuclear aromatic hydrocarbons (PAHs). Kidney cell types were separated by density gradient centrifugation and single cell suspensions of macrophages were used for in vitro studies. Chemotactic activity was measured in Boyden chambers using Escherichia coli as the chemotactic stimulus. The percentage of macrophages migrating was maximal at 90 min but was markedly reduced in Elizabeth River fish (spot, 33%; hogchoker, 56%) as compared to clean water controls (spot, 55%; hogchoker, 85%). Macrophage phagocytosis of bacteria was quantified by the microscopic enumeration of the proportion of phagocytes which contained intracellular bacteria. Phagocytic activity reached maximum values within 120 min and remained relatively constant for the remainder of the experiment. Phagocytic activity was reduced significantly in the fish obtained from the Elizabeth River. Values at 120 min were 74% and 19% for spot from the c...Continue Reading

References

Sep 29, 1978·Annals of the New York Academy of Sciences·R M Overstreet, H D Howse
Aug 1, 1985·Bulletin of Environmental Contamination and Toxicology·R E WolkeC J George

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Citations

Nov 1, 1989·Archives of Environmental Contamination and Toxicology·A WishkovskyB A Weeks
Nov 1, 1989·Archives of Environmental Contamination and Toxicology·A D Deshpande
Jan 1, 1990·Developmental and Comparative Immunology·A J Ainsworth, D X Chen
Sep 1, 1990·Veterinary Immunology and Immunopathology·A J AinsworthT Greenway
Feb 7, 1994·Toxicology·P W WesterW B van Muiswinkel
Dec 17, 2003·Fish & Shellfish Immunology·A K NayakS C Mukherjee
Aug 10, 2007·Journal of Toxicology and Environmental Health. Part a·Lee A FrederickCharles D Rice
Feb 19, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ayako NakayamaHelmut Segner
Mar 19, 2014·Marine Environmental Research·Yenny RisjaniChristophe Minier
Sep 1, 1989·Rapid Communications in Mass Spectrometry : RCM·J Greaves, R H Bieri
Oct 27, 2018·Anais Da Academia Brasileira De Ciências·Jaqueline D Biller, Leonardo S Takahashi
Jun 5, 2017·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Elizabeth R JonesRobert J Griffitt

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