Functional evidence confirmed by histological localization: overlapping expression of erythropoietin and HIF-2alpha in interstitial fibroblasts of the renal cortex

Kidney International
Hayo Castrop, Armin Kurtz

Abstract

Erythropoietin (EPO) is the central hormone in the regulation of erythropoiesis. Synthesis of EPO and its constitutive release into the circulation are controlled by the transcriptional activity of the EPO gene. A key regulator of EPO is the dimeric hypoxia-inducible transcription factor (HIF), which has three isoforms. Paliege and co-workers provide convincing morphological evidence that it is the HIF-2 isoform that essentially triggers EPO in the kidney, which is the primary source of EPO in the body.

References

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Feb 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michaela GruberM Celeste Simon

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Citations

Aug 25, 2012·Molecular Biology of the Cell·Michael FählingRalf Mrowka
Sep 1, 2017·Journal of Cellular and Molecular Medicine·Gemma OlmosDiego Rodríguez-Puyol
Apr 4, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhongnan YangFengmin Shao

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