PMID: 7033396Jan 1, 1982Paper

Functional evidence for complement-activating immune complexes in the skin of patients with bullous pemphigoid

The Journal of Investigative Dermatology
W R GammonJ R Carlo

Abstract

Previous immunofluorescent studies showing deposits of immunoglobulin and complement at the cutaneous basement membrane zone have provided evidence supporting a role for immune complexes in the pathogenesis of bullous pemphigoid. In this study the functional activity of the deposits has been examined using leukocyte attachment, a method for detecting and quantitating the biological activity of complement-activating immune complexes in tissues. When peripheral blood leukocytes suspended in serum complement were incubated with cryostat sections of lesional and adjacent normal-appearing skin from 9 patients with pemphigoid, skin from 11 normal controls and lesional skin from 14 nonpemphigoid disease controls there was significantly greater attachment of leukocytes to the basement membrane zone of lesional bullous pemphigoid skin compared to normal-appearing pemphigoid skin and skin of both control groups. A significant reduction in attachment in the absence of serum complement suggested the reaction was dependent on activation of complement by tissue-deposited complexes. Although leukocyte attachment was greater in lesional than normal-appearing pemphigoid skin, a comparison of the incidence and intensity of cutaneous IgG and comp...Continue Reading

Citations

Jun 1, 1995·The British Journal of Dermatology·J A YellS M Burge
Jan 1, 1997·Lupus·J A Yell, F Wojnarowska
Feb 22, 2017·Indian Dermatology Online Journal·Varsha M ShettyRaghavendra Rao
Jan 1, 1984·Archives of Dermatological Research·A R AhmedV Arab-Kermani
Jul 8, 1982·The New England Journal of Medicine·R D Sontheimer, J N Gilliam
May 29, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·E Dabelsteen
Jul 1, 1985·The Journal of Investigative Dermatology·R E JordonK A Fritz

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