PMID: 7540658Jul 1, 1995Paper

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis

The Journal of Experimental Medicine
B L McRaeS D Miller

Abstract

The role of epitope spreading in the pathology of relapsing-remitting experimental autoimmune encephalomyelitis (R-EAE) was examined. Using peripherally induced immunologic tolerance as a probe to analyze the neuropathologic T cell repertoire, we show that the majority of the immunopathologic reactivity during the acute phase of R-EAE in SJL/J mice induced by active immunization with the intact proteolipid (PLP) molecule is directed at the PLP139-151 epitope and that responses to secondary encephalitogenic PLP epitopes may contribute to the later relapsing phases of disease. Intermolecular epitope spreading was demonstrated by showing the development of T cell responses to PLP139-151 after acute disease in mice in which R-EAE was initiated by the transfer of T cells specific for the non-cross-reactive MBP84-104 determinant. Intramolecular epitope spreading was demonstrated by showing that endogenous host T cells specific for a secondary encephalitogenic PLP epitope (PLP178-191) are demonstrable by both splenic T cell proliferative and in vivo delayed-type hypersensitivity responses in mice in which acute central nervous system damage was initiated by T cells reactive with the immunodominant, non-cross-reactive PLP139-151 sequen...Continue Reading

References

Jan 1, 1992·International Reviews of Immunology·S D MillerW J Karpus
Jun 1, 1987·Journal of the Neurological Sciences·J L TrotterJ D Scarpellini
Apr 1, 1988·Journal of the Neurological Sciences·U Traugott, P Lebon
May 1, 1993·Immunology Today·P V LehmannG Gammon
Aug 1, 1994·Immunology Today·S D Miller, W J Karpus
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S FatenejadJ Craft

❮ Previous
Next ❯

Citations

Oct 4, 2000·Reviews in Medical Virology·G J AtkinsB J Sheahan
Mar 29, 2002·European Journal of Immunology·Todd N EagarStephen D Miller
Sep 25, 2002·Journal of Neuroscience Research·Hong Yan LiuHalina Offner
Feb 1, 1997·Immunologic Research·I S Grewal, R A Flavell
Feb 28, 1998·Immunologic Research·C S ConstantinescuA M Rostami
Jan 1, 1996·Immunologic Research·G BenichouE V Fedoseyeva
Apr 17, 2007·Journal of Clinical Immunology·Farzin ForooghianHans-Michael Dosch
Dec 14, 2011·Clinical Reviews in Allergy & Immunology·Maria De Santis, Carlo Selmi
Nov 19, 2011·Clinical Reviews in Allergy & Immunology·Matthew F CusickRobert S Fujinami
Apr 20, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Juliane KlehmetThomas G Forsthuber
Mar 9, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F MartínezJ Berenguer
May 28, 2013·Trends in Immunology·Sarah B SimmonsJoan M Goverman
Jun 16, 2000·Journal of Neuroimmunology·V K Tuohy, P M Mathisen
Nov 1, 1996·Journal of Neuroimmunology·R R VoskuhlM D Dalcq
Jul 30, 1999·Journal of Neuroimmunology·W F Hickey
Jun 1, 1996·Blood Reviews·J SchultzeJ G Gribben
Jan 29, 1999·Research in Immunology·S D Miller, E M Shevach
Dec 5, 2000·Current Opinion in Immunology·S MocciM Howard
Dec 1, 1996·Current Opinion in Immunology·C J Vanderlugt, S D Miller
Nov 5, 1999·Nature Medicine·T Kielian, W F Hickey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.