Functional evidence for the differential control of superficial and deep blood vessels by sympathetic vasoconstrictor and primary afferent vasodilator fibres in rat hairless skin

Experimental Brain Research
H J HäblerW Jänig

Abstract

We quantitatively investigated sympathetic vasoconstriction and antidromic vasodilation mediated by small-diameter primary afferents on the plantar hairless skin of the hindpaws in Wistar rats using laser Doppler (LD) flowmetry and an infrared thermometer. Sympathetic vasoconstriction was elicited by electrical stimulation of the centrally cut ipsilateral lumbar sympathetic trunk (LST) with 50-s trains at 0.1-20 Hz. Antidromic vasodilation was evoked by electrical stimulation of the dorsal root (DR) L5 with 20-s or 50-s trains at 1-4 Hz. Cutting the LST resulted in increases in skin temperature (SKT) by 6.1 +/- 1.0 degrees C (mean +/- SEM) and in LD flow by 128 +/- 20%. Stimulation of the LST resulted in a graded decrease in LD flow and SKT that was most pronounced between 0 and 0.1 Hz. However, DR stimulation evoked a large increase in LD flow but only little change in SKT in rats with sectioned LST. When the DR was stimulated either in animals with intact LST or during continuous stimulation of vasoconstrictor fibres in the sectioned LST, i.e. while baseline temperature was relatively low (26.3 +/- 1.1 degrees C), DR stimulation still resulted in large increases in LD flow, but only minor changes in SKT. These results suggest...Continue Reading

Citations

Mar 22, 2003·Autonomic Neuroscience : Basic & Clinical·Satoshi TanakaRobert D Foreman
Dec 1, 2004·Journal of Spinal Disorders & Techniques·Akira OndaShinichi Kikuchi
Apr 9, 2005·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·J AdolphsM Schafer
Oct 6, 2009·Experimental Neurology·Wilfrid Jänig
Jun 30, 2009·The Journal of Pain : Official Journal of the American Pain Society·Saurav ShresthaGary R Strichartz
Sep 8, 2010·Brain Research·Christopher E HagainsYuan B Peng
Jan 2, 2007·Regional Anesthesia and Pain Medicine·Robert WerdehausenMarkus F Stevens
Dec 3, 2017·Journal of Clinical Laboratory Analysis·Jianlong HanChunzheng Gao
Jul 6, 2002·Pain·Gunnar WasnerRalf Baron
Aug 13, 1999·The American Journal of Physiology·H M StaussH J Häbler

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