Functional Evidence of Pulmonary Extracellular Vesicles in Infectious and Noninfectious Lung Inflammation

The Journal of Immunology : Official Journal of the American Association of Immunologists
Heedoo LeeYang Jin

Abstract

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a highly complex process that can be triggered by both noninfectious (sterile) and infectious stimuli. Inflammatory lung responses are one of the key features in the pathogenesis of this devastating syndrome. How ALI/ARDS-associated inflammation develops remains incompletely understood, particularly after exposure to sterile stimuli. Emerging evidence suggests that extracellular vesicles (EVs) regulate intercellular communication and inflammatory responses in various diseases. In this study, we characterized the generation and function of pulmonary EVs in the setting of ALI/ARDS, induced by sterile stimuli (oxidative stress or acid aspiration) and infection (LPS/Gram-negative bacteria) in mice. EVs detected in bronchoalveolar lavage fluid (BALF) were markedly increased after exposure of animals to both types of stimuli. After sterile stimuli, alveolar type-І epithelial cells were the main source of the BALF EVs. In contrast, infectious stimuli-induced BALF EVs were mainly derived from alveolar macrophages (AMs). Functionally, BALF EVs generated in both the noninfectious and infectious ALI models promoted the recruitment of macrophages in in vivo mouse models....Continue Reading

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Citations

Mar 21, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mark J McVeyWolfgang M Kuebler
Feb 29, 2020·American Journal of Respiratory Cell and Molecular Biology·Rahul Y MahidaMichael A Matthay
Jun 27, 2019·The Journal of Experimental Medicine·Heedoo LeeYang Jin
Jun 17, 2020·Experimental & Molecular Medicine·Joshua Holtzman, Heedoo Lee
Feb 20, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Heedoo LeeYang Jin
Oct 6, 2020·Frontiers in Immunology·Atsushi MuraoPing Wang
Jul 10, 2020·Respiratory Research·Aradhana MohanNavneet K Dhillon
Dec 12, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Heedoo LeeYang Jin
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Nov 13, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ling DingDavid Oupický
Jan 14, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Heedoo LeeYang Jin
May 1, 2021·International Journal of Molecular Sciences·Lukasz ZarebaMalgorzata Czystowska-Kuzmicz
Mar 21, 2021·Immunology·Xiaohuan XiaJialin C Zheng
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