Functional evolution of a morphogenetic gradient

ELife
Chun Wai KwanUrs Schmidt-Ott

Abstract

Bone Morphogenetic Proteins (BMPs) pattern the dorsal-ventral axis of bilaterian embryos; however, their roles in the evolution of body plan are largely unknown. We examined their functional evolution in fly embryos. BMP signaling specifies two extraembryonic tissues, the serosa and amnion, in basal-branching flies such as Megaselia abdita, but only one, the amnioserosa, in Drosophila melanogaster. The BMP signaling dynamics are similar in both species until the beginning of gastrulation, when BMP signaling broadens and intensifies at the edge of the germ rudiment in Megaselia, while remaining static in Drosophila. Here we show that the differences in gradient dynamics and tissue specification result from evolutionary changes in the gene regulatory network that controls the activity of a positive feedback circuit on BMP signaling, involving the tumor necrosis factor alpha homolog eiger. These data illustrate an evolutionary mechanism by which spatiotemporal changes in morphogen gradients can guide tissue complexity.

References

Aug 7, 2004·Science·Dave KosmanEthan Bier
Dec 22, 2005·Development·Michael B O'ConnorSeth S Blair
Oct 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Maurijn van der ZeeSiegfried Roth
Jan 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ab Matteen RafiqiUrs Schmidt-Ott
Apr 16, 2008·Developmental Cell·Rodrigo Nunes da FonsecaSiegfried Roth
May 1, 2010·Development·Steffen LemkeUrs Schmidt-Ott
Feb 22, 2011·Bioinformatics·Diego DarribaDavid Posada
Apr 5, 2011·Cold Spring Harbor Protocols·Ab Matteen RafiqiUrs Schmidt-Ott
Sep 20, 2011·Molecular Phylogenetics and Evolution·Alexis Criscuolo
Aug 10, 2012·Development·Ab Matteen RafiqiUrs Schmidt-Ott
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Feb 2, 2013·Trends in Genetics : TIG·Ben-Zion ShiloNaama Barkai
Jun 6, 2013·Current Opinion in Genetics & Development·Kristi A Wharton, Mihaela Serpe
Nov 5, 2013·Current Biology : CB·Jackie Gavin-SmythEdwin L Ferguson
Jan 11, 2014·PloS One·Karl R WottonJohannes Jaeger
Oct 24, 2014·Annual Review of Entomology·Antónia Monteiro
Jul 21, 2016·Current Opinion in Insect Science·Urs Schmidt-Ott, Chun Wai Kwan

Datasets Mentioned

BETA
AAF50328.2
AAF50329.1
AAF50331.1

Methods Mentioned

BETA
PCR

Related Concepts

Metazoa
Diptera
Tadpole
Gene Expression Regulation, Developmental
Bone Morphogenetic Proteins
Embryonic Pattern Formation
Gene Modules
Drosophila
Drosophila melanogaster
Embryo

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.