Functional flexibility of intestinal IgA - broadening the fine line.

Frontiers in Immunology
Emma SlackSiegfried Hapfelmeier

Abstract

Intestinal bacteria outnumber our own human cells in conditions of both health and disease. It has long been recognized that secretory antibody, particularly IgA, is produced in response to these microbes and hypothesized that this must play an important role in defining the relationship between a host and its intestinal microbes. However, the exact role of IgA and the mechanisms by which IgA can act are only beginning to be understood. In this review we attempt to unravel the complex interaction between so-called "natural," "primitive" (T-cell-independent), and "classical" IgA responses, the nature of the intestinal microbiota/intestinal pathogens and the highly flexible dynamic homeostasis of the mucosal immune system. Such an analysis reveals that low-affinity IgA is sufficient to protect the host from excess mucosal immune activation induced by harmless commensal microbes. However, affinity-maturation of "classical" IgA is essential to provide protection from more invasive commensal species such as segmented filamentous bacteria and from true pathogens such as Salmonellatyphimurium. Thus a correlation is revealed between "sophistication" of the IgA response and aggressiveness of the challenge. A second emerging theme is tha...Continue Reading

Citations

Oct 9, 2013·Fish & Shellfish Immunology·Daniela GomezIrene Salinas
Jun 20, 2013·Nature Immunology·Eric M BrownB Brett Finlay
May 22, 2013·Clinical & Developmental Immunology·Anouk K GloudemansHermelijn H Smits
Jan 27, 2015·Cell Host & Microbe·Jason L KubinakJune L Round
Dec 5, 2015·Frontiers in Immunology·Ludovica F ButtóDirk Haller
May 7, 2014·Cellular Microbiology·Charisse Petersen, June L Round
Dec 24, 2014·Gut Microbes·Amandine MathiasBlaise Corthésy
Dec 9, 2014·Gut Microbes·Jennifer L GommermanJörg H Fritz
Mar 1, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jason M ShapiroNeal S LeLeiko
Jul 9, 2016·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Ruijun ZhangHua-Xin Liao
Apr 17, 2016·Clinical and Experimental Immunology·R Salerno-GoncalvesM B Sztein
Mar 19, 2016·Arthritis & Rheumatology·Mark J AsquithJames T Rosenbaum
Jan 13, 2018·FEMS Microbiology Reviews·Pascale VonaeschPhilippe J Sansonetti
Feb 24, 2019·Nature Reviews. Nephrology·Felix KnaufRichard A Flavell
Oct 28, 2017·Frontiers in Immunology·Špela KonjarMarc Veldhoen
Oct 30, 2012·Nature Reviews. Immunology·Oliver Pabst
Jul 8, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Magdalena A BerkowskaMenno C van Zelm
Jan 17, 2019·Journal of Immunology Research·Ebony N Gary, Michele A Kutzler
Jul 1, 2020·Journal of Nutritional Science·Utsav P TiwariRyan N Dilger
Jan 7, 2017·Journal of Experimental & Clinical Cancer Research : CR·Houbao ZhuZhu-Gang Wang
Apr 6, 2021·Frontiers in Immunology·Olusegun O Onabajo, Joseph J Mattapallil
Jul 25, 2021·International Journal of Molecular Sciences·Hitomi SuginoMotonobu Nakamura

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