PMID: 25769345Mar 15, 2015Paper

Functional genomic analysis reveals overlapping and distinct features of chronologically long-lived yeast populations

Aging
Margaret B WiermanJeffrey S Smith

Abstract

Yeast chronological lifespan (CLS) is extended by multiple genetic and environmental manipulations, including caloric restriction (CR). Understanding the common changes in molecular pathways induced by such manipulations could potentially reveal conserved longevity mechanisms. We therefore performed gene expression profiling on several long-lived yeast populations, including anade4∆mutant defective in de novo purine (AMP) biosynthesis, and a calorie restricted WT strain. CLS was also extended by isonicotinamide (INAM) or expired media derived from CR cultures. Comparisons between these diverse long-lived conditions revealed a common set of differentially regulated genes, several of which were potential longevity biomarkers. There was also enrichment for genes that function in CLS regulation, including a long-lived adenosine kinase mutant (ado1∆) that links CLS regulation to the methyl cycle and AMP. Genes co-regulated between the CR and ade4∆ conditions were dominated by GO terms related to metabolism of alternative carbon sources, consistent with chronological longevity requiring efficient acetate/acetic acid utilization. Alternatively, treating cells with isonicotinamide (INAM) or the expired CR media resulted in GO terms pre...Continue Reading

References

Mar 24, 2009·Cell Cycle·Christopher R BurtnerMatt Kaeberlein
Feb 12, 2010·BMC Biology·Silke FuchsArmand M Leroi
Apr 28, 2010·PLoS Genetics·Mirela MatecicJeffrey S Smith
Oct 27, 2010·Microbial Cell Factories·Nuno P MiraIsabel Sá-Correia
Dec 7, 2013·Aging and Disease·Sara C Zapico, Douglas H Ubelaker
May 27, 2014·Longevity & Healthspan·Dao-Fu DaiPeter S Rabinovitch

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Citations

Apr 5, 2017·Molecular and Cellular Biology·Margaret B WiermanJeffrey S Smith
Sep 7, 2017·Antioxidants & Redox Signaling·Jared S LorussoVyacheslav M Labunskyy
Nov 28, 2020·The Journal of Biological Chemistry·Elisa Enriquez-HeslesJeffrey S Smith
Jan 19, 2021·The Journal of Biological Chemistry·Elisa Enriquez-HeslesJeffrey S Smith

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