Functional genomics and proteomics as a foundation for systems biology

Briefings in Functional Genomics & Proteomics
Kunal Aggarwal, Kelvin H Lee

Abstract

Developments in high-throughput measurement technologies for biological molecules have created a paradigm shift in modern life science research. The field of systems biology attempts to provide a systems-level understanding by systematically organising the genomic, functional genomic and proteomic data obtained from genetic and environmental perturbations of interest and using the data to build a descriptive and mechanistic model of the biological phenomena. The goal is to build a mathematical framework with some predictive abilities. This review highlights the need for system-level understanding, lists some of the high-throughput measurement tools of importance in systems biology, reviews various types of experimental and computational approaches being used in systems biology research and attempts to address some of the challenges facing this research community.

Citations

Jul 9, 2009·Molecular BioSystems·Andreas BernthalerBernd Mayer
Mar 27, 2012·Molecular BioSystems·Ioannis N MelasLeonidas G Alexopoulos
Dec 1, 2011·Reproduction, Fertility, and Development·Mark BurkittAlireza Fazeli
Aug 22, 2012·Briefings in Functional Genomics·Ferenc JordánWei-Chung Liu
Jun 16, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Muna AffaraCristin Print
Feb 16, 2011·Infection and Immunity·Ferric C Fang, Arturo Casadevall
Nov 28, 2006·Biochemistry. Biokhimii︠a︡·S Ivakhno, A Kornelyuk
Jul 26, 2011·Journal of Parasitology Research·Marcos A Vannier-Santos, Henrique L Lenzi
Sep 12, 2008·Theoretical Biology & Medical Modelling·Annick Lesne, Arndt Benecke
May 22, 2008·Theoretical Biology & Medical Modelling·Annick Lesne, Arndt Benecke
Nov 17, 2009·Theoretical Biology & Medical Modelling·Andrés PinzónSilvia Restrepo
Mar 17, 2010·BMC Systems Biology·Derek Gatherer
May 13, 2008·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Ping Li, Li-Ping Yang
Sep 7, 2005·Pharmacogenomics·Wei-Wei Zhang
Dec 11, 2013·Molecular Neurobiology·Ramavati PalSimon Geir Møller
Jun 19, 2007·Poultry Science·H-C S Liu, J A Hicks
Oct 27, 2009·Acta Biotheoretica·Philippe De BackerLinda Van Speybroeck
Sep 4, 2008·Proteomics·Nadine Kabbani
Nov 22, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Maureen A O'Malley, John Dupré
Mar 17, 2006·The New Phytologist·John H F Bothwell
Nov 28, 2012·Proteomics. Clinical Applications·Bernice WrightJonathan M Gibbins
Jul 5, 2012·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Fulvio Mazzocchi
Jan 19, 2006·Mutation Research·Mary Helen Barcellos-Hoff, Sylvain V Costes
Aug 12, 2009·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Ping LiYue-wen Gong
Jul 25, 2015·Applied Microbiology and Biotechnology·João Pinto da CostaRui Vitorino
Mar 31, 2007·Journal of Biomedical Informatics·Eleftherios PanterisXiaohui Liu
Sep 1, 2007·Proteomics. Clinical Applications·Philip DoranKay Ohlendieck
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Patrick Aloy, Robert B Russell
Dec 13, 2005·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Zhenran Jiang, Yanhong Zhou
Nov 26, 2005·Expert Review of Proteomics·Robert S KuczenskiKelvin H Lee
Jan 11, 2005·The Journal of Burn Care & Rehabilitation·Ankush Gosain, Richard L Gamelli
Dec 9, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Joachim D Pleil, Linda S Sheldon
Aug 4, 2005·Acta Biochimica Et Biophysica Sinica·Yun HuangJun Yang
Jan 11, 2021·Briefings in Bioinformatics·Jana Musilova, Karel Sedlar
Dec 1, 2020·Frontiers in Cell and Developmental Biology·Mustafa Sertbas, Kutlu O Ulgen
Apr 24, 2007·The Journal of Experimental Biology·Dietmar KültzJinoo Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved