Functional genomics based on germline genome-wide association studies of endocrine therapy for breast cancer.

Pharmacogenomics
Jacqueline ZayasLiewei Wang

Abstract

Breast cancer is the most common invasive cancer in women worldwide. Functional follow-up of breast cancer genome-wide association studies has led to the discovery of genes that regulate endocrine therapy response in a SNP- and drug-dependent manner. Here, we will present four examples in which functional genomic studies from breast cancer clinical trials led to novel pharmacogenomic insights and molecular mechanisms of selective estrogen receptor modulators and aromatase inhibitors. The approach utilized for studying genetic variability described in this review offers substantial potential for meaningful discoveries that move the field toward precision medicine for patients.

References

Jun 7, 2006·JAMA : the Journal of the American Medical Association·Victor G VogelUNKNOWN National Surgical Adjuvant Breast and Bowel Project (NSABP)
Apr 1, 2010·Cancer Research·James N IngleRichard M Weinshilboum
Apr 21, 2010·Cancer Prevention Research·Victor G VogelUNKNOWN National Surgical Adjuvant Breast and Bowel Project
Jun 8, 2010·BMC Genomics·Krishna R KalariRichard M Weinshilboum
Sep 30, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James N IngleRichard M Weinshilboum
Jul 22, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiang-Lin TanLiewei Wang
Jan 30, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul E GossLois E Shepherd
Mar 23, 2013·Molecular Endocrinology·Mohan LiuRichard M Weinshilboum
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Feb 26, 2015·Pharmacogenomics·Nifang Niu, Liewei Wang
Jul 28, 2015·Lancet·UNKNOWN Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
Mar 30, 2018·The Journal of Pharmacology and Experimental Therapeutics·Ming-Fen HoRichard Weinshilboum
Dec 6, 2018·International Journal of Molecular Sciences·Drew R NeavinRichard M Weinshilboum
May 31, 2019·Nature Reviews. Molecular Cell Biology·Adrian Pickar-Oliver, Charles A Gersbach

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
reverse transcription PCR
immunoprecipitation
ChIP
ubiquitination
ChIP-seq
methyl-seq

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Gan to kagaku ryoho. Cancer & chemotherapy
Akira MatsuiMasaki Kitajima
Expert Review of Endocrinology & Metabolism
Mohit K VermaHironobu Sasano
Duodecim; lääketieteellinen aikakauskirja
Heikki Joensuu
© 2022 Meta ULC. All rights reserved