Functional genomics of PPAR-gamma in human immunomodulatory cells.

Molecular and Cellular Biochemistry
Deepak KaulAmit Khanna

Abstract

Keeping in view the fact that peroxisome-proliferators activated receptors-PPARs (alpha,gamma) play a crucial role in atherogenic inflammation, the present study was addressed to explore as to how selective and specific PPAR-gamma gene silencing within human mononuclear cells affects genes involved in lipid metabolism and innate immune process. Such a study revealed that with respect to control cells, the PPAR-gamma knock-out cells exhibited significant reduction in the expression of genes coding for PPAR- alpha, CD-36, LDL-R as well as significant increase in the expression of genes coding for IL-4, IL-8, IFN-gamma, CX3CR1, hTERT. However, the expression of genes coding for LXR-alpha and Receptor-C( k ) could not be detected in PPAR-gamma knock-out cells. Based on these results, we propose that PPAR-gamma gene has the inherent capacity to influence the lipid mediated inflammation process in atherosclerotic lesions.

References

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Citations

Oct 25, 2016·BioFactors·Ekaterina Vladimirovna Fomenko, Yuling Chi
Jun 8, 2006·Molecular and Cellular Biochemistry·Deepak KaulKavleen Sikand
Dec 22, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Minjia ZhuYi Zhu
Dec 17, 2010·World Journal of Cardiology·Vivek Priy Dave, Deepak Kaul

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