Functional genomics: paving the way for more successful cancer immunotherapy

Briefings in Functional Genomics
Reham AjinaLouis M Weiner

Abstract

Immunotherapies have revolutionized cancer treatment. Immunotherapy is effective for the treatment of a wide range of cancer types and can mediate complete and durable tumor regression. Nonetheless, the field still faces many significant challenges, such as the need for personalized therapeutic strategies and better biomarkers, the difficulty of selecting the right combination therapy, and resistance to currently available immunotherapies. Both cancer and host immunity comprise significantly diverse and complex ecosystems, making immunogenomics an ideal field for functional genomics analysis. In this review, we describe the cancer-immunity cycle, how cancer cells manage to evade immune attack and the current hurdles in the path of cancer immunotherapy. Then, we discuss how functional genomics approaches can pave the way for more successful cancer immunotherapies.

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Citations

Mar 23, 2019·Briefings in Functional Genomics·An-Liang XiaXiao-Jie Lu
Sep 11, 2019·Neuro-oncology·Jessica B FosterAngela J Waanders
Sep 7, 2019·Current Opinion in Hematology·Celina MontemayorMargaret A Keller
Aug 25, 2020·Pancreas·Reham Ajina, Louis M Weiner
Jun 6, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yuka NakajimaTasuku Honjo

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