Functional genomics to identify unforeseen cancer drug targets

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Functional genomics to identify unforeseen cancer drug targets

Abstract

References

Integrating genetic approaches into the discovery of anticancer drugs

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis

A resource for large-scale RNA-interference-based screens in mammals

The concept of synthetic lethality in the context of anticancer therapy

Cell biology: divining cancer cell weaknesses

Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions

DNA-PK suppresses a p53-independent apoptotic response to DNA damage

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

The combined status of ATM and p53 link tumor development with therapeutic response

Systematic mapping of genetic interaction networks

Chronic treatment with a selective inhibitor of casein kinase I delta/epsilon yields cumulative phase delays in circadian rhythms

Towards systematic functional characterization of cancer genomes

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

Functional viability profiles of breast cancer

A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis

MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency

Deregulated MYC expression induces dependence upon AMPK-related kinase 5

The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer

Functional genomics identifies therapeutic targets for MYC-driven cancer

An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders

Drug Repurposing for Cancer Therapy

Citations

The opportunity for microbiopsies for skin cancer

Building high-resolution synthetic lethal networks: a 'Google map' of the cancer cell

BIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues

Related Concepts

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Ataxia telangiectasia (MDS)

Ataxia telangiectasia

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