Functional glutamatergic and glycinergic inputs to several superior olivary nuclei of the rat revealed by optical imaging

Neuroscience
Geetha SrinivasanStefan Löhrke

Abstract

Superior olivary complex (SOC) neurons receive excitatory and inhibitory inputs from both ears. We determined the nature of such inputs to the main SOC nuclei with an optical imaging system. To do so, brainstem slices of postnatal (P) rats (P3-13) were treated with the fast voltage-sensitive dye RH795, and ipsilateral and contralateral SOC inputs were activated electrically. Optical signals, equivalent to membrane potential changes, were detected by a 464-photodiode array. The signals consisted mostly of two components which were identified as pre- and postsynaptic potentials in experiments with Ca2+-free solutions. They correlated with morphological structures, i.e. the presynaptic components were prominent in neuropil regions whereas the postsynaptic components dominated in somata regions. Postsynaptic components were distinguished pharmacologically with the glycine receptor blocker strychnine and the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)/kainate receptor blocker 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). Concerning the lateral superior olive, we confirmed the known glutamatergic inputs from the ipsilateral side and the glycinergic inputs from the ipsilateral and contralateral sides. Furthermore, we id...Continue Reading

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Citations

Feb 17, 2005·Cell and Tissue Research·Peter BlaesseHans Gerd Nothwang
Sep 17, 2008·Hearing Research·Heike EhmannHans Gerd Nothwang
Nov 24, 2005·The Journal of Comparative Neurology·Eric D BurasRichard A Altschuler
Oct 14, 2014·Frontiers in Neural Circuits·Stefanie C AltieriStephen M Maricich
Apr 30, 2015·Brain Structure & Function·Fei Gao, Albert S Berrebi

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