Functional heterogeneity at dopamine release sites.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
James A DanielB Vissel

Abstract

Although drugs used to treat several neurological diseases are presumed to target synapses that secrete dopamine (DA), relatively little is known about synaptic vesicle (SV) release mechanisms at single DA synapses. We found that the relative probability of release (Pr) varied between individual DA synapses. Furthermore, DA terminals generally exhibited lower Pr than glutamatergic hippocampal (Hpc) terminals, suggesting that DA release is less reliable than the release of glutamate. Our mathematical model of fluorescence loss shows that Pr is regulated by two independent and heterogeneous elements. First, the size of the recycling SV pool regulates Pr. Second, Pr is also independently regulated by additional factors, which are reflected in the time constant of FM 1-43 destaining, tau. We found that the observed difference in Pr between Hpc and DA neurons results because the recycling SV pool is smaller in DA neurons than in Hpc neurons. However, tau does not vary between these two neuron populations. We also identified a population of functional nonsynaptic boutons in DA axons, which are not associated with a postsynaptic element and which are not functionally different from boutons that formed conventional synapses. Our work p...Continue Reading

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Citations

Jun 2, 2011·Cognitive Neurodynamics·R D SamsonJean-Marc Fellous
Jul 7, 2012·Nature Protocols·James A DanielPhillip J Robinson
Jan 24, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anjali RaoAlexander Sorkin
Jun 11, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bibiana OnoaRobert H Edwards
Sep 24, 2011·Neuroscience·M E RiceS J Cragg
May 1, 2012·Neuron·Daniela HernandezDavid Sulzer
Jul 16, 2013·Neurobiology of Learning and Memory·Gary P MorrisBryce Vissel
Jul 10, 2020·ChemPlusChem·Meshkat DinarvandSebastian Kruss
Mar 7, 2020·Acta Pharmacologica Sinica·Changliang Liu
Feb 16, 2019·Current Opinion in Neurobiology·Changliang Liu, Pascal S Kaeser
Apr 11, 2021·Nature Reviews. Neuroscience·Changliang LiuPascal S Kaeser
May 17, 2019·Neuroscience and Biobehavioral Reviews·Fiona LimanaqiFrancesco Fornai
Jul 29, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Charles DucrotLouis-Eric Trudeau

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