Functional heterogeneity of arcuate nucleus pro-opiomelanocortin neurons: implications for diverging melanocortin pathways.

Molecular Neurobiology
Jong-Woo Sohn, Kevin W Williams

Abstract

Arcuate nucleus (ARC) pro-opiomelanocortin (POMC) neurons are essential regulators of food intake, energy expenditure, and glucose homeostasis. POMC neurons integrate several key metabolic signals that include neurotransmitters and hormones. The change in activity of POMC neurons is relayed to melanocortin receptors in distinct regions of the central nervous system. This review will summarize the role of leptin and serotonin receptors in regulating the activity of POMC neurons and provide a model in which different melanocortin pathways regulate energy and glucose homeostasis.

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Citations

Jun 25, 2013·Trends in Neurosciences·Jong-Woo SohnKevin W Williams
Jun 5, 2014·Cellular and Molecular Life Sciences : CMLS·Jin Kwon JeongByung Ju Lee
May 18, 2013·Biochimica Et Biophysica Acta·Clemence Girardet, Andrew A Butler
Apr 15, 2015·Frontiers in Neuroanatomy·Daqing WangCheng Zhan
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Apr 24, 2012·The Journal of Comparative Neurology·Brooke C Jarvie, Shane T Hentges
Dec 7, 2018·British Journal of Pharmacology·Zhenyan HeKevin W Williams
Feb 28, 2019·The Journal of Endocrinology·Giulia Baldini, Kevin D Phelan
Jul 15, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hong WangSanna Lehtonen
Aug 10, 2013·Endocrinology·Casey C NestorRobert L Goodman
Sep 23, 2020·Pflügers Archiv : European journal of physiology·Jong-Woo Sohn, Won-Kyung Ho
Apr 18, 2018·Molecular Neurobiology·Ilaria BaroneMargherita Maffei
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Aug 24, 2021·Frontiers in Neuroendocrinology·João Paulo Cavalcanti-de-Albuquerque, José Donato
Sep 23, 2021·JCI Insight·Zhenyan HeKevin W Williams
Jul 2, 2020·Physiology & Behavior·Linh LieuKevin W Williams

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