PMID: 6990979Apr 15, 1980Paper

Functional heterogeneity of Escherichia coli ribonucleic acid polymerase holoenzyme

Biochemistry
A A TraversP G Debenham

Abstract

On zone sedimentation Escherichia coli RNA polymerase holoenzyme exhibits functional heterogeneity with respect to template preference, regulation by ppGpp, and affinity for fMet-tRNA. The template preference of a subpopulation of RNA polymerase molecules correlates with both its sedimentation position and its ability to respond to effectors of polymerase selectivity. Incubation of such functionally distinct populations of enzyme molecules at physiological temperatures results in functional and structural equivalence. We suggest that RNA polymerase normally exists as a mixture of interconvertible forms and that promoter selection can be controlled by varying the number and proportions of forms present.

References

May 1, 1976·Cell·A J van OoyenP Jorgensen
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Jul 11, 1978·Molecular & General Genetics : MGG·P JørgensenK von Meyenbourg
Aug 19, 1976·Molecular & General Genetics : MGG·A Travers
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·O Pongs, N Ulbrich
Oct 15, 1976·FEBS Letters·A Travers
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·K BackmanW Gilbert
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Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P G DebenhamA A Travers

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Citations

Aug 25, 1982·Nucleic Acids Research·A A TraversH A Mace
Jan 1, 1987·CRC Critical Reviews in Biochemistry·A A Travers
Jun 1, 1988·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A A Travers
Feb 1, 1982·Archives of Biochemistry and Biophysics·S IharaM Kawakami
Jul 25, 1980·Journal of Molecular Biology·A A Travers
Jan 1, 1983·Zeitschrift für allgemeine Mikrobiologie·K Riedel
Dec 1, 1995·Microbiological Reviews·C CondonC L Squires

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