Functional high-intensity training improves pancreatic β-cell function in adults with type 2 diabetes

American Journal of Physiology. Endocrinology and Metabolism
Stephan NieuwoudtJohn P Kirwan

Abstract

Type 2 diabetes (T2D) is characterized by reductions in β-cell function and insulin secretion on the background of elevated insulin resistance. Aerobic exercise has been shown to improve β-cell function, despite a subset of T2D patients displaying "exercise resistance." Further investigations into the effectiveness of alternate forms of exercise on β-cell function in the T2D patient population are needed. We examined the effect of a novel, 6-wk CrossFit functional high-intensity training (F-HIT) intervention on β-cell function in 12 sedentary adults with clinically diagnosed T2D (54 ± 2 yr, 166 ± 16 mg/dl fasting glucose). Supervised training was completed 3 days/wk, comprising functional movements performed at a high intensity in a variety of 10- to 20-min sessions. All subjects completed an oral glucose tolerance test and anthropometric measures at baseline and following the intervention. The mean disposition index, a validated measure of β-cell function, was significantly increased (PRE: 8.4 ± 3.1, POST: 11.5 ± 3.5, P = 0.02) after the intervention. Insulin processing inefficiency in the β-cell, expressed as the fasting proinsulin-to-insulin ratio, was also reduced (PRE: 2.40 ± 0.37, POST: 1.78 ± 0.30, P = 0.04). Increased β...Continue Reading

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Citations

Jan 3, 2019·American Journal of Physiology. Endocrinology and Metabolism·Mark V PintiJohn M Hollander
Nov 7, 2019·The Journal of Physiology·Martin J Gibala, Jonathan P Little
Oct 5, 2017·Frontiers in Endocrinology·Melissa L EricksonKevin K McCully
Sep 29, 2020·Frontiers in Endocrinology·Mina WangPeng Wei
Sep 5, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Addisu Dabi Wake
Nov 28, 2018·Journal of Functional Morphology and Kinesiology·Ramires Alsamir TibanaFabrício Azevedo Voltarelli
Mar 7, 2021·International Journal of Environmental Research and Public Health·Sultan Ayoub MeoAnusha Sultan Meo
Apr 20, 2021·The Journal of Clinical Endocrinology and Metabolism·John P KirwanPhilip R Schauer
Dec 16, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Li WangChenggui Liu

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Methods Mentioned

BETA
ELISA
X-ray

Software Mentioned

GraphPad Prism
CrossFit

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