Functional holography of recorded neuronal networks activity

Neuroinformatics
Itay Baruchi, E Ben-Jacob

Abstract

We present a new approach for analyzing multi-channel recordings, such as ECoG (electrocorticograph) recordings of cortical brain activity and of individual neuron dynamics, in cultured networks. The latter are used here to illustrate the method and its ability to discover hidden functional connectivity motifs in the recorded activity. The cultured networks are formed from dissociated mixtures of cortical neurons and glia-cells that are homogeneously spread over multi-electrode array for recording of the neuronal activity. Rich, spontaneous dynamical behavior is detected, marked by the formation of temporal sequences of synchronized bursting events (SBEs), partitioned into statistically distinguishable subgroups, each with its own characteristic spatio-temporal pattern of activity.In analogy with coherence connectivity networks for multi-location cortical recordings, we evaluated the inter-neuron correlation-matrix for each subgroup. Ordinarily such matrices are mapped onto a connectivity network between neuron positions in real space. In our functional holography, the correlations are normalized by the correlation distances Euclidian distances between the matrix columns. Then, we project the N-dimensional (for N channels) spac...Continue Reading

Citations

Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Asaf MadiEshel Ben-Jacob
Nov 1, 2008·The European Journal of Neuroscience·Itay BaruchiEshel Ben-Jacob
Apr 9, 2008·IEEE Transactions on Bio-medical Engineering·Jan StegengaWim L C Rutten
Apr 12, 2016·Frontiers in Systems Neuroscience·Yuichiro YadaHirokazu Takahashi
Oct 4, 2005·Journal of Bioscience and Bioengineering·Fabrice O MorinEiichi Tamiya
Feb 6, 2007·Journal of Neuroscience Methods·Jack WaddellMichal Zochowski
Oct 6, 2005·Physical Biology·Vladislav VolmanEshel Ben-Jacob
Aug 7, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Itay Baruchi, Eshel Ben-Jacob
Sep 11, 2008·Physical Biology·Mark SheinEshel Ben-Jacob
Oct 2, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Qingyun WangGuanrong Chen
Feb 16, 2012·Journal of Neural Engineering·Ling WangEnric Claverol-Tinturé
Jan 7, 2015·Physical Biology·Virginia PirinoPaolo Massobrio
Apr 20, 2010·Neurotoxicology·Andrew F M JohnstoneTimothy J Shafer

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