Functional hydroxyapatite bioceramics with excellent osteoconductivity and stern-interface induced antibacterial ability

Biomaterials Science
Chao ShiYingchun Zhu

Abstract

The biocompatibility and antibacterial properties of hydroxyapatite (HAp) bioceramics are crucial in medical applications. However, it is still a challenge to control HAp with antibacterial ability while maintaining other biological properties in the development of bioactive bone implants. Herein, we report functional silver ion substituted HAp bioceramics with excellent osteoconductivity and efficient antibacterial activity and propose a stern-interface induced antibacterial mechanism of such bioactive ceramics. In this antibacterial process, the concentration of Ag(+) at the stern-interface of Ag/HAp bioceramics is nearly 5 times higher than that in the bulk solution due to the trace dopant Ag(+) enrichment in the stern layer of the electric double layer at the negatively charged surface of Ag/HAp bioceramics. Trace Ag-doping in HAp induces a positive shift of zeta potential and increase of hydrophilicity, which may help inhibit bacterial proliferation. The positive osteoblast adhesion, proliferation and differentiation of ultra-trace doped Ag/HAp are also demonstrated through actin cytoskeleton staining, MTT and alkaline phosphatase (ALP) activity assays. This work may enlighten us on the artificial design of novel smart ant...Continue Reading

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Citations

Mar 19, 2019·Journal of Biomaterials Applications·Juan J Martínez-SanmiguelCristina Rodríguez-Padilla
Apr 11, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Aditi PandeyKantesh Balani
Aug 2, 2021·International Journal of Pharmaceutics·Qichun SongMariappan Rajan
Jan 3, 2020·ACS Applied Materials & Interfaces·T MokabberY T Pei
Nov 16, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yanting LyuHiroshi Uyama

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