Functional hypersomatotropism in small for gestational age (SGA) newborn infants

The Journal of Clinical Endocrinology and Metabolism
M DeiberB Salle

Abstract

Basal plasma GH levels and the GH responses to an injection of 1 microgram/kg 1-44(NH2) GHRH were determined on day 3 postnatally in 5 small gestational age (SGA) twin newborns and their appropriate gestational age (AGA) co-twins, and in 10 SGA singleton newborns and 6 AGA singleton newborns. The mean basal plasma GH level was higher in the SGA than in the AGA infants but the difference was significant only for singleton newborns (p less than 0.01). The mean peak plasma GH level was markedly increased in SGA compared to AGA infants (p less than 0.05 for twins, p less than 0.01 for singletons). Twelve SGA infants re-tested at 1 month had lower basal and peak plasma GH levels (p less than 0.001 and p less than 0.01). In 21 SGA and 17 AGA infants, serum IGF-I, measured by RIA between 12 and 96 hours after birth, was significantly higher in SGA than in AGA (p less than 0.001). These results suggest that, whatever the mechanism, functional hypersomatotropism is present at day 3 in SGA infants. This hypersomatotropism may participate in the early catch-up growth process.

Citations

Nov 29, 2005·Reviews in Endocrine & Metabolic Disorders·Harriet L MilesWayne S Cutfield
Oct 9, 2002·Trends in Endocrinology and Metabolism : TEM·Richard I G Holt
Sep 1, 1999·Clinical Endocrinology·D E FlanaganD I Phillips
Apr 4, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·T TakeuchiY Iikura
Oct 1, 1996·Acta Paediatrica. Supplement·P D GluckmanB H Breier
Jul 23, 2004·Archives of Disease in Childhood·L B Johnston, M O Savage
Oct 1, 1995·Archives of Disease in Childhood·C H FallD J Barker
Sep 8, 2007·Hormone Research·P ChatelainW Sippell
Dec 14, 2007·BMC Medical Informatics and Decision Making·Jovanna DahlgrenKerstin Albertsson-Wikland
Jan 1, 1993·The Journal of Pediatric Endocrinology·E E MüllerF Camanni
Nov 1, 1996·Journal of Pediatric Endocrinology & Metabolism : JPEM·H GarcíaF Cassorla
Dec 24, 1997·Journal of Pediatric Endocrinology & Metabolism : JPEM·E BartolottaE Ghigo
Nov 26, 1998·Journal of Pediatric Endocrinology & Metabolism : JPEM·M BozzolaR M Schimpff
May 1, 1993·Acta Paediatrica·K Albertsson-WiklandS Rosberg
Feb 19, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Primus-E Mullis, Paolo Tonella
Jul 19, 2013·International Journal of Pediatrics·Adriana C VidalCathrine Hoyo
Dec 6, 2005·The Journal of Veterinary Medical Science·Masayuki YokoyamaKeiko Nakahara
Feb 9, 2002·QJM : Monthly Journal of the Association of Physicians·N K ArdenT D Spector
Jan 26, 2002·British Medical Bulletin·C D Byrne
Mar 3, 2004·Circulation·Atul SinghalAlan Lucas
Jul 27, 2006·Journal of Neuroendocrinology·T PrinsH A Delemarre-van de Waal
Oct 1, 1996·Acta Paediatrica. Supplement·P G ChatelainJ L Chaussain
Feb 27, 2007·Endocrine Reviews·Paul SaengerEdward O Reiter
Oct 7, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Miles J De BlasioJulie A Owens
Dec 1, 2017·Nutrition Reviews·Daniel J HoffmanDaniel B Hardy
Apr 30, 1999·Physiological Reviews·E E MüllerD Cocchi
Jul 3, 2021·International Journal of Molecular Sciences·Shelby L Oke, Daniel B Hardy
Jul 3, 2021·Children·Anastasios Papadimitriou, Dimitrios T Papadimitriou
Aug 19, 2021·Indian Journal of Pediatrics·Wayne Cutfield, Ahila Ayyavoo

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