PMID: 6412144Sep 15, 1983Paper

Functional identity between murine gamma interferon and macrophage activating factor

R M Schultz, W J Kleinschmidt


We have previously suggested that two lymphokine activities-macrophage activating factor (MAF) and gamma interferon (IFN-gamma)-are mediated by the same molecule. Striking similarities were noted in their cellular biosynthesis, rate of inactivation with acid treatment and heating, and elution profiles on Sephacryl S-200. In addition, highly specific polyclonal antibodies to murine IFN-gamma neutralized MAF and IFN-gamma to a similar degree. However, definitive studies require a pure product and we now report that murine IFN-gamma that had been cloned and expressed in a simian nonlymphoid cell line shows MAF activity. But it is not yet known whether IFN-gamma is responsible for all the MAF activity in media conditioned by T cells as the possibility for MAF heterogeneity remains.


Jan 1, 1982·Journal of Interferon Research·W J Kleinschmidt, R M Schultz
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·W R BenjaminJ J Farrar
Jan 1, 1982·Journal of Interferon Research·W K Roberts, A Vasil
Dec 1, 1982·The Journal of Experimental Medicine·P S SteegJ J Oppenheim
Apr 1, 1982·Cellular Immunology·T L RatliffW J Catalona
Sep 1, 1982·The Journal of Experimental Medicine·R D SchreiberD H Katz
Jun 15, 1980·International Journal of Cancer. Journal International Du Cancer·A MantovaniR B Herberman


Jan 1, 1990·Archives of Dermatological Research·C Skoglund, A Scheynius
Nov 1, 1985·Journal of Clinical Immunology·R L HirschK P Johnson
May 1, 1987·Veterinary Immunology and Immunopathology·S W Russell, J L Pace
Jun 1, 1992·Veterinary Immunology and Immunopathology·G EntricanD M Haig
Oct 1, 1985·Antiviral Research·K W McIntyreR M Welsh
Jan 1, 1988·International Journal of Immunopharmacology·G L Warner, D A Lawrence
Jan 1, 1990·International Journal of Immunopharmacology·H MatsumuraM Nakano
Jan 1, 1991·International Journal of Immunopharmacology·J L Stewart-PhillipsN C Phillips
Apr 16, 1991·Biochimica Et Biophysica Acta·M Stoker, E Gherardi
Nov 1, 1996·Journal of Dermatological Science·T MiyataS Nishiyama
Nov 1, 1989·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·G GarottaM Fountoulakis
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J B WeinbergM A Misukonis
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D A EppsteinA B Schreiber
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H M Johnson, B A Torres
Jul 1, 1984·The Journal of Experimental Medicine·A CeladaR D Schreiber
Nov 1, 1993·The Journal of Experimental Medicine·K AndoF V Chisari
Jun 1, 1988·Journal of Interferon Research·D A EppsteinC G Kurahara
Jun 1, 1990·Endodontics & Dental Traumatology·P Stashenko
Dec 9, 2003·The British Journal of Ophthalmology·S BanerjeeS M Nicholls
Sep 7, 2001·Environmental Health Perspectives·V CastranovaJ K Ma
Feb 15, 2014·Journal of Cancer Research and Clinical Oncology·Jie ZhangYu Jiang
Mar 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yoshiaki ShimizuM Wayne Flye
Feb 1, 1993·Journal of Neuroimmunology·Y Kuroda, M Matsui
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L M CollettiR M Strieter
Oct 1, 1989·Immunobiology·J N Ijzermans, R L Marquet
Dec 1, 1990·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·W RoszkowskiJ Jeljaszewicz
Dec 1, 1988·Immunobiology·C M JonesR K Shadduck
Mar 5, 2016·Oncoimmunology·Ole Audun Werner HaabethAlexandre Corthay
Apr 6, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases· AbhimanyuMridula Bose
Aug 11, 2010·Veterinary Immunology and Immunopathology·J WitchellM Goyal
Sep 1, 1992·Journal of Endodontics·P StashenkoC Y Wang
Oct 1, 1988·Arthritis and Rheumatism·N J MauritzL Klareskog
Oct 1, 1984·European Journal of Immunology·P W AndrewD B Lowrie
Mar 1, 1987·Scandinavian Journal of Immunology·P ArturssonJ L Ericsson
Apr 1, 1985·Australian and New Zealand Journal of Medicine·D S Nelson, C L Geczy
Jan 1, 1985·Microbiology and Immunology·K ImaiA Tanaka
Aug 30, 1985·Biochemical and Biophysical Research Communications·B A Torres, H M Johnson
Nov 22, 2012·Oncoimmunology·Ole Audun Werner HaabethAlexandre Corthay
Oct 4, 2016·Frontiers in Immunology·Maria Fernanda PascuttiMartijn A Nolte
Nov 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O Le MoineJ Devière
Apr 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J DevièreE Dupont
Jan 1, 1986·Journal of Cellular Physiology·B Fagg, C A Roitsch
Apr 25, 2008·Current Protocols in Immunology·A H Fortier
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C SoulasP Jeannin
Jan 1, 1989·Seminars in Surgical Oncology·B E Nelson, E C Borden
Jan 1, 1990·Springer Seminars in Immunopathology·S SinclairG Levy
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Osamu ShimozatoHoward A Young
Dec 29, 2000·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·J PayneK C Chadha

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.