PMID: 6412144Sep 15, 1983Paper

Functional identity between murine gamma interferon and macrophage activating factor

Nature
R M Schultz, W J Kleinschmidt

Abstract

We have previously suggested that two lymphokine activities-macrophage activating factor (MAF) and gamma interferon (IFN-gamma)-are mediated by the same molecule. Striking similarities were noted in their cellular biosynthesis, rate of inactivation with acid treatment and heating, and elution profiles on Sephacryl S-200. In addition, highly specific polyclonal antibodies to murine IFN-gamma neutralized MAF and IFN-gamma to a similar degree. However, definitive studies require a pure product and we now report that murine IFN-gamma that had been cloned and expressed in a simian nonlymphoid cell line shows MAF activity. But it is not yet known whether IFN-gamma is responsible for all the MAF activity in media conditioned by T cells as the possibility for MAF heterogeneity remains.

References

Jan 1, 1982·Journal of Interferon Research·W J Kleinschmidt, R M Schultz
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·W R BenjaminJ J Farrar
Jan 1, 1982·Journal of Interferon Research·W K Roberts, A Vasil
Dec 1, 1982·The Journal of Experimental Medicine·P S SteegJ J Oppenheim
Apr 1, 1982·Cellular Immunology·T L RatliffW J Catalona
Sep 1, 1982·The Journal of Experimental Medicine·R D SchreiberD H Katz
Jun 15, 1980·International Journal of Cancer. Journal International Du Cancer·A MantovaniR B Herberman

❮ Previous
Next ❯

Citations

Jan 1, 1990·Archives of Dermatological Research·C Skoglund, A Scheynius
Nov 1, 1985·Journal of Clinical Immunology·R L HirschK P Johnson
May 1, 1987·Veterinary Immunology and Immunopathology·S W Russell, J L Pace
Jun 1, 1992·Veterinary Immunology and Immunopathology·G EntricanD M Haig
Oct 1, 1985·Antiviral Research·K W McIntyreR M Welsh
Jan 1, 1988·International Journal of Immunopharmacology·G L Warner, D A Lawrence
Jan 1, 1990·International Journal of Immunopharmacology·H MatsumuraM Nakano
Jan 1, 1991·International Journal of Immunopharmacology·J L Stewart-PhillipsN C Phillips
Apr 16, 1991·Biochimica Et Biophysica Acta·M Stoker, E Gherardi
Nov 1, 1996·Journal of Dermatological Science·T MiyataS Nishiyama
Nov 1, 1989·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·G GarottaM Fountoulakis
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J B WeinbergM A Misukonis
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D A EppsteinA B Schreiber
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H M Johnson, B A Torres
Jul 1, 1984·The Journal of Experimental Medicine·A CeladaR D Schreiber
Nov 1, 1993·The Journal of Experimental Medicine·K AndoF V Chisari
Jun 1, 1988·Journal of Interferon Research·D A EppsteinC G Kurahara
Jun 1, 1990·Endodontics & Dental Traumatology·P Stashenko
Dec 9, 2003·The British Journal of Ophthalmology·S BanerjeeS M Nicholls
Sep 7, 2001·Environmental Health Perspectives·V CastranovaJ K Ma
Feb 15, 2014·Journal of Cancer Research and Clinical Oncology·Jie ZhangYu Jiang
Mar 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yoshiaki ShimizuM Wayne Flye
Feb 1, 1993·Journal of Neuroimmunology·Y Kuroda, M Matsui

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.