Functional imaging--schizophrenia

British Medical Bulletin
P F Liddle

Abstract

Evidence from recent studies of brain function in schizophrenia confirms that the frontal underactivity reported in earlier studies is a feature only of cases with decreased psychomotor activity, while patients with different symptom profile have different patterns of cerebral activity. Each of the three major groups of schizophrenic symptoms reflects a specific pattern of aberrant cerebral activity in association cortex of frontal, parietal and temporal lobes, and in related subcortical nuclei. These patterns indicate imbalances between neuronal activity at diverse interconnected brain sites, rather than abnormal function at a single location. Furthermore, during the performance of executive tasks, schizophrenic subjects exhibit impaired frontal activation, while during memory tasks there a tendency towards impaired temporal lobe activation. The difficulty activating a particular region does not reflect fixed loss of function. Rather the evidence indicates that the characteristic feature of schizophrenia is disturbed connectivity between cerebral areas.

Citations

Mar 12, 2008·Annals of Biomedical Engineering·Andreas WindemuthGualberto Ruaño
Feb 16, 1999·Schizophrenia Research·M P PaulusD L Braff
Jun 23, 1998·Current Opinion in Neurobiology·C Frith, R J Dolan
Jul 11, 2007·Psychiatric Genetics·Nobuhisa MaenoNorio Ozaki
Mar 2, 2011·The British Journal of Psychiatry : the Journal of Mental Science·John P JohnSanjeev Jain
May 21, 1999·The Australian and New Zealand Journal of Psychiatry·E Gordon
Nov 9, 2000·The International Journal of Neuroscience·L M WilliamsH Bahramali
Oct 19, 2010·Progress in Neurobiology·Nagahide TakahashiJoseph D Buxbaum
Nov 26, 2008·Schizophrenia Research·Owen R PhillipsKatherine L Narr
Nov 1, 2013·Research in Developmental Disabilities·Yan Grace Lam
Mar 10, 2004·International Review of Neurobiology·Daniel G Stewart, Kenneth L Davis
Jul 26, 2017·Medical & Biological Engineering & Computing·Mehmet Akif ÖzçobanAydin Akan
Mar 24, 2018·European Archives of Psychiatry and Clinical Neuroscience·Máté BaraditsPál Czobor
Dec 3, 1999·American Journal of Medical Genetics·T H WassinkN C Andreasen

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