Functional imaging in Lhermitte-Duclose disease

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Madakasira V PadmaJoseph C Mantil

Abstract

A comprehensive metabolic characterization of a patient with dysplastic gangliocytoma of the cerebellum or Lhermitte-Duclos Disease (LDD) is presented. Assessment using 2-deoxy-2-[18F]fluoro-D-glucose (FDG), carbon-11-labeled methionine (11C-MET), carbon-11-labeled choline (11C-Choline) positron emission tomography (PET), and 1H-proton magnetic resonance spectroscopy (MRS) was carried out in a 30-year-old Caucasian woman. FDG-PET revealed hypermetabolism of the tumor. 11C-MET-PET revealed moderate uptake and 11C-Choline showed no uptake. 1H-MRS demonstrated an elevated level of lactate and decreased levels of choline (Cho) and myoinositol. Functional imaging in LDD reflects the dual pathological features of neoplasm and hamartoma.

Citations

Oct 24, 2014·Neuroradiology·Patrice Jissendi-TchofoAnthony James Barkovich
May 28, 2016·Neurosurgical Review·Ferdinando Franco CalabriaGiuseppe Lucio Cascini
Aug 29, 2018·Clinical Nuclear Medicine·Eve PiekarskiAurélie Kas
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