Functional imaging of hepatocellular carcinoma using diffusion-weighted MRI and (18)F-FDG PET/CT in patients on waiting-list for liver transplantation

Cancer Imaging : the Official Publication of the International Cancer Imaging Society
Samia BoussouarAlain Luciani

Abstract

To compare the apparent diffusion coefficient (ADC) on diffusion-weighted imaging (DWI) with the standardized uptake values (SUV) measured by(18)F-FDG-PET/CT in naïve hepatocellular carcinoma (HCC) nodules, and to determine whether these markers are associated with tumours at high-risk of aggressiveness. From 2007 to 2010, all patients with HCC on the waiting list for liver transplantation and who underwent both FDG-PET/CT and 1.5-T DWI-MRI (b values: 0, 200, 400, and 800 s/mm(2)) were included in this institutional review board-approved retrospective study. Tumour size, tumour ADC, tumour-to-liver ADC ratio (ADCT/L), maximal tumour SUV and tumour-to-liver SUV ratio (SUVT/L) were measured and compared to serum alpha-fetoprotein (AFP) levels, tumour size and differentiation grade on explanted specimens. A total of 37 HCC nodules in 28 patients were available for correlation between MRI and PET/CT, 7 of which (in 7 patients) showed a SUVT/L > 1.15. We did not find any correlation between tumour ADC or ADCT/L and tumour SUV or SUVT/L. To note, SUVT/L was positively correlated with AFP levels (R = 0.95, P ≤ 0.0001), while ADCT/L was not (P = 0.73). Twenty-four patients (with 32 nodules) underwent liver transplantation. In this subg...Continue Reading

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Citations

Dec 22, 2017·Annals of Hepato-biliary-pancreatic Surgery·Kyung Jin ChoA Ri Chong
Aug 11, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Armin Finkenstedt, Heinz Zoller
Oct 11, 2017·World Journal of Hepatology·Anuradha Shenoy-BhangleAvinash Kambadakone
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Nov 8, 2018·Contrast Media & Molecular Imaging·Stefanie J HectorsBachir Taouli
Nov 8, 2018·Contrast Media & Molecular Imaging·Vincenzo CuccurulloGiuseppe Lucio Cascini
Mar 1, 2020·Academic Radiology·Filiz ÇelebiCem Balcı
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Methods Mentioned

BETA
on

Software Mentioned

RAMLA
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Syntegra
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