Functional imaging of intratumoral hypoxia

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Serene S FooAndrew M Scott

Abstract

Tumor hypoxia plays a fundamental role in tumor progression and treatment resistance. Recent evidence that hypoxia also influences the regulation and transcription of various genes involved in malignant growth and metastases, and promotes a more aggressive tumor phenotype makes its diagnosis even more important. The evidence for the biology of hypoxia in tumors, and imaging of hypoxia with different technologies was reviewed through literature review and Medline searches, and clinical studies with 18F-fluoromisonidazole (FMISO) Positron Emission Tomography (PET). Until recently, determination of the level of tumor oxygenation was only possible using invasive methods that limited its clinical application. Imaging techniques that have shown promise in assessing hypoxia include magnetic resonance imaging and spectroscopy, single photon emission computed tomography (SPECT) and PET. Quantitative hypoxia measurement with 18F-FMISO PET in patients with malignant gliomas and lung cancer have demonstrated intratumoural hypoxia and dissociation of glucose metabolism from hypoxia in some cases, indicating the complex nature of cellular metabolic response to stress. The emerging role of therapies that have improved efficacy in hypoxic cond...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·E LartigauM Guichard
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·U KreutzerT Jue
Dec 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J A RaleighP S Allen
Mar 1, 1991·International Journal of Radiation Oncology, Biology, Physics·J M Brown, M J Lemmon
Jan 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J D Chapman
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Jan 1, 1990·Free Radical Research Communications·H M Swartz
Oct 1, 1990·International Journal of Radiation Oncology, Biology, Physics·F KallinowskiP Vaupel
Jul 1, 1990·Circulation Research·G V MartinK A Krohn
Jan 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H BruhnR Sauter
Apr 1, 1989·International Journal of Radiation Oncology, Biology, Physics·R J MaxwellJ R Griffiths
Jul 1, 1986·International Journal of Radiation Oncology, Biology, Physics·R C UrtasunC J Koch
Dec 1, 1988·Stroke; a Journal of Cerebral Circulation·J W Berkelbach van der SprenkelJ A den Hollander
May 1, 1988·International Journal of Radiation Oncology, Biology, Physics·R A GatenbyG J Broder
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·G C RiceR T Schimke
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·H J HalpernB A Teicher
Feb 1, 1995·Mutation Research·D W FairbairnK L O'Neill
Oct 15, 1994·International Journal of Radiation Oncology, Biology, Physics·D M BrizelM W Dewhirst
Jun 15, 1994·International Journal of Radiation Oncology, Biology, Physics·R RamplingP Workman
Apr 30, 1994·International Journal of Radiation Oncology, Biology, Physics·R RodriguezT J Kinsella
Jul 15, 1993·International Journal of Radiation Oncology, Biology, Physics·P OkunieffP Vaupel
Jan 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M HöckelP Vaupel
Mar 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R P MasonP P Antich
Apr 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S K HollandJ C Gore
Jul 1, 1996·International Journal of Radiation Oncology, Biology, Physics·M NordsmarkJ Overgaard
Jan 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B GallezH M Swartz
Sep 1, 1996·International Journal of Radiation Oncology, Biology, Physics·J S RaseyK A Krohn
Oct 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M NordsmarkJ Overgaard
May 1, 1997·International Journal of Radiation Oncology, Biology, Physics·D M BrizelM W Dewhirst
Aug 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H LyngE K Rofstad
Oct 23, 1997·International Journal of Radiation Oncology, Biology, Physics·J R GriffithsH Baddeley
Nov 22, 1997·International Journal of Radiation Oncology, Biology, Physics·F EschwegeB Luboinski

❮ Previous
Next ❯

Citations

Aug 18, 2005·Journal of the American Chemical Society·Raymond P BriñasSergei A Vinogradov
Nov 5, 2008·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Alan JacksonSamantha Mills
May 23, 2012·Journal of Biomedical Optics·Ratan K SahaMichael C Kolios
Feb 15, 2005·American Journal of Respiratory and Critical Care Medicine·Martin P L BardJoachim G J V Aerts
Dec 10, 2009·Medical Physics·Jenghwa ChangC Clifton Ling
May 25, 2012·The British Journal of Radiology·I Mendichovszky, A Jackson
Apr 29, 2014·Nuclear Medicine and Biology·Evelyn LaurensUwe Ackermann
May 17, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jørgen van den BogaardMichel C Ollers
Feb 16, 2011·Cancer Treatment Reviews·Judith van LoonDirk De Ruysscher
Sep 11, 2010·Trends in Biotechnology·Cyril Petibois, Bernard Desbat
Feb 26, 2010·European Journal of Radiology·W Wadsak, M Mitterhauser
Jan 5, 2010·PET Clinics·Suzanne E LapiMichael J Welch
Mar 31, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hugo J W L AertsDirk De Ruysscher
Dec 19, 2008·Critical Reviews in Oncology/hematology·Dimitri PapathanassiouHervé Curé
Jun 12, 2008·Seminars in Oncology·Kenneth A Krohn, Bevan Yeuh
Feb 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Hugo J W L AertsDirk De Ruysscher
Oct 9, 2007·Seminars in Nuclear Medicine·Sze Ting Lee, Andrew M Scott
Aug 7, 2007·International Journal of Radiation Oncology, Biology, Physics·Aste SøvikDag Rune Olsen
Mar 6, 2007·International Journal of Radiation Oncology, Biology, Physics·Vincent A BourkeRalph P Mason
Jan 24, 2007·Critical Reviews in Oncology/hematology·Yazid BelkacémiDavid Azria
Jan 25, 2011·NMR in Biomedicine·Jesús Pacheco-TorresSebastián Cerdán
Jun 1, 2011·Seminars in Nuclear Medicine·Shankar VallabhajosulaBrigitte Vallabhajosula
May 27, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kari TanderupCai Grau
Nov 29, 2005·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·Y BelkacémiE Lartigau
Feb 5, 2008·Seminars in Nuclear Medicine·Chandan GuhaShalom Kalnicki
Jun 9, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ly-Binh-An TranBernard Gallez
Mar 20, 2008·International Journal of Biomedical Imaging·Taiwei ChuXiangyun Wang
Mar 30, 2007·Radiation Research·Anna S E LjungkvistAlbert J van der Kogel
Jul 26, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hugo J W L AertsDirk De Ruysscher
Feb 24, 2015·Seminars in Nuclear Medicine·Christopher BellStephen Rose
Feb 24, 2015·Seminars in Nuclear Medicine·Paul N Span, Johan Bussink
Jan 9, 2007·The Cancer Journal·John P Kirkpatrick
Sep 21, 2006·Physics in Medicine and Biology·Eirik MalinenDag Rune Olsen
Jul 2, 2008·Nature Reviews. Drug Discovery·Jürgen K WillmannSanjiv S Gambhir
Aug 30, 2008·Annals of Nuclear Medicine·Ayse MaviAbass Alavi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis