PMID: 8971865Nov 1, 1996Paper

Functional imaging of tumours with 99Tcm-sestamibi pinhole scintigraphy

Nuclear Medicine Communications
S KoukourakiM Koukourakis

Abstract

This study presents the advantages of pinhole over parallel-hole scintigraphy in the assessment of 99Tcm-sestamibi-related tumour biology. Twenty-five patients with malignancies underwent 99Tcm-sestamibi scintigraphy (Cardiolite, Dupont) before radiotherapy, 10 of whom had repeat scintigrams after the delivery of 25 Gy and at the end of radiotherapy. A total of 45 scintigrams with parallel-hole and pinhole collimation were evaluated for tumour avidity and ability to provide images for differential biological analysis within the tumour (areas of different uptake) or beyond the main mass (multifocality, satellite tumoral foci). The pinhole collimator was located with precision over the tumour area using a radiotherapy simulator. In 19 of 45 (42%) parallel-hole scintigrams the tumours were non-avid, whereas in 13 of 45 (29%) the tumours could be identified but the image quality was very poor. In contrast, tumour avidity was assessed in all 25 cases (100%) using pinhole scintigraphy and all pinhole images were evaluable for assessment of 99Tcm-sestamibi biology. The tumour-to-normal tissue (T/N) count ratio for the tumoral centre ranged from 1.71 to 4.36 (median 3.07) vs 1.54 to 3.20 (median 2.18) at the periphery, as assessed by p...Continue Reading

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.