Functional imaging reveals rapid reorganization of cortical activity after parietal inactivation in monkeys.

Proceedings of the National Academy of Sciences of the United States of America
Melanie WilkeR A Andersen

Abstract

Impairments of spatial awareness and decision making occur frequently as a consequence of parietal lesions. Here we used event-related functional MRI (fMRI) in monkeys to investigate rapid reorganization of spatial networks during reversible pharmacological inactivation of the lateral intraparietal area (LIP), which plays a role in the selection of eye movement targets. We measured fMRI activity in control and inactivation sessions while monkeys performed memory saccades to either instructed or autonomously chosen spatial locations. Inactivation caused a reduction of contralesional choices. Inactivation effects on fMRI activity were anatomically and functionally specific and mainly consisted of: (i) activity reduction in the upper bank of the superior temporal sulcus (temporal parietal occipital area) for single contralesional targets, especially in the inactivated hemisphere; and (ii) activity increase accompanying contralesional choices between bilateral targets in several frontal and parieto-temporal areas in both hemispheres. There was no overactivation for ipsilesional targets or choices in the intact hemisphere. Task-specific effects of LIP inactivation on blood oxygen level-dependent activity in the temporal parietal occ...Continue Reading

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Citations

Apr 12, 2013·Journal of Cognitive Neuroscience·Melanie WilkeRichard A Andersen
May 9, 2013·Brain Structure & Function·Arkadeb DuttaNeeraj Jain
Feb 18, 2016·Current Opinion in Neurobiology·Carlos D Brody, Timothy D Hanks
Jan 19, 2016·Frontiers in Systems Neuroscience·Mitchell R Riley, Christos Constantinidis
Jan 12, 2016·Nature Neuroscience·Yan T WongBijan Pesaran
Nov 26, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daniil P AksenovAlice M Wyrwicz
Mar 22, 2014·Cerebral Cortex·Olivier GuipponiSuliann Ben Hamed
Aug 8, 2014·Neuron·Wim VanduffelGuy A Orban
Mar 20, 2014·Cerebral Cortex·Bianca de HaanHans-Otto Karnath
Mar 13, 2014·Neuron·Richard A AndersenMarkus Hauschild
Jan 23, 2015·Brain : a Journal of Neurology·Marine LunvenPaolo Bartolomeo
Jan 8, 2015·Frontiers in Neuroscience·Anirban DuttaDavid Guiraud
Sep 14, 2016·Trends in Neurosciences·Bijan Pesaran, David J Freedman
Jan 6, 2017·Neuron·Timothy D Hanks, Christopher Summerfield
Sep 24, 2015·PLoS Computational Biology·Vassilios Christopoulos, Paul R Schrater
Apr 5, 2017·ELife·Srivatsun SadagopanWinrich A Freiwald
Nov 8, 2013·Journal of Neurophysiology·Eric A YttriLawrence H Snyder
Aug 5, 2017·Annual Review of Neuroscience·Alexander C HukJacob L Yates
Apr 4, 2018·Proceedings of the National Academy of Sciences of the United States of America·Eric Mooshagian, Lawrence H Snyder
Jun 7, 2018·Scientific Reports·Vassilios N ChristopoulosRichard A Andersen
Aug 8, 2020·Frontiers in Behavioral Neuroscience·Mario TreviñoBelén Haro
Mar 28, 2019·Frontiers in Neural Circuits·Kostas HadjidimitrakisMaureen A Hagan
Dec 11, 2020·PLoS Biology·Thomas ThieryKarim Jerbi
Feb 26, 2021·ILAR Journal·David J SchaefferStefan Everling
Apr 2, 2021·NeuroImage·P Christiaan KlinkChristopher I Petkov
Apr 19, 2021·Cerebral Cortex·I Caprara, P Janssen
Sep 4, 2021·Frontiers in Neural Circuits·Eun Jung HwangTatsuo K Sato

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