Functional Imaging with Nucleic-Acid-Based Sensors: Technology, Application and Future Healthcare Prospects

Chembiochem : a European Journal of Chemical Biology
Christian WirajaChenjie Xu

Abstract

Timely monitoring and assessment of human health plays a crucial role in maintaining the wellbeing of our advancing society. In addition to medical tools and devices, suitable probe agents are crucial to assist such monitoring, either in passive or active ways (i.e., sensors) through inducible signals. In this review we highlight recent developments in activatable optical sensors based on nucleic acids. Sensing mechanisms and bio-applications of these nucleic acid sensors in ex vivo assays, intracellular or in vivo settings are described. In addition, we discuss the limitations of these sensors and how nanotechnology can complement/enhance sensor properties to promote translation into clinical applications.

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Citations

May 30, 2020·Molecular Pharmaceutics·Mingyue CuiChenjie Xu
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Peter Jonas Wickhorst, Heiko Ihmels

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