Functional Impairment Is a Risk Factor for Knee Replacement in the Multicenter Osteoarthritis Study

Clinical Orthopaedics and Related Research
B L WiseMichael Nevitt

Abstract

Debilitating pain associated with knee osteoarthritis (OA) often leads patients to seek and complete total knee arthroplasty (TKA). To date, few studies have evaluated the relation of functional impairment to the risk of TKA, despite the fact that OA is associated with functional impairment. The purpose of our study was to (1) evaluate whether function as measured by WOMAC physical function subscale was associated with undergoing TKA; and (2) whether any such association varied by sex. The National Institutes of Health-funded Multicenter Osteoarthritis Study (MOST) is an observational cohort study of persons aged 50 to 79 years with or at high risk of symptomatic knee OA who were recruited from the community. All eligible subjects with complete data were included in this analysis. Our study population sample consisted of 2946 patients with 5796 knees; 1776 (60%) of patients were women. We performed a repeated-measures analysis using baseline WOMAC physical function score to predict the risk of TKA from baseline to 30 months and WOMAC score at 30 months to predict risk of incident TKA from 30 months to 60 months. We used generalized estimating equations to account for the correlation between two knees within an individual and ac...Continue Reading

References

Jan 1, 1996·The Journal of Arthroplasty·C A MancusoM E Charlson
Apr 18, 2001·The Journal of Arthroplasty·K D KellyM E Suarez-Almazor
Oct 19, 2004·Rheumatic Diseases Clinics of North America·David T Felson, Michael C Nevitt
Apr 22, 2006·American Journal of Preventive Medicine·Margaret ShihCharles G Helmick
Oct 3, 2006·Arthritis and Rheumatism·Gabriella M van DijkUNKNOWN Carpa Study Group
Aug 28, 2012·Clinical Orthopaedics and Related Research·Gregory G PolkowskiRobert L Barrack
Dec 25, 2012·Biology of Sex Differences·Daniel P NicolellaWendy M Kohrt

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Citations

Apr 14, 2016·Osteoarthritis and Cartilage·S T SkouUNKNOWN Multicenter Osteoarthritis Study Group
Apr 7, 2020·The Journal of Bone and Joint Surgery. American Volume·Samantha M MeintsKristin L Schreiber
Sep 26, 2020·Therapeutic Advances in Musculoskeletal Disease·Jorge A Roman-BlasGabriel Herrero-Beaumont

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