Functional impairment of renal afferent arteriolar voltage-gated calcium channels in rats with diabetes mellitus

The Journal of Clinical Investigation
P K CarminesH Ikenaga

Abstract

Experiments were performed to test the hypothesis that diabetes mellitus is associated with impaired afferent arteriolar responsiveness to opening of voltage-gated calcium channels. Diabetes was induced by injection of streptozocin (65 mg/kg, i.v.) and insulin was administered via an osmotic minipump to achieve moderate hyperglycemia. Sham rats received vehicle treatments. 2 wk later, the in vitro blood-perfused juxtamedullary nephron technique was used to allow videomicroscopic measurement of afferent arteriolar contractile responses to increasing bath concentrations of either Bay K 8644 or K+. Baseline afferent arteriolar diameter in kidneys from diabetic rats (26.4+/-1.2 microm) exceeded that of Sham rats (19.7+/-1.0 microm). Bay K 8644 evoked concentration-dependent reductions in afferent diameter in both groups of kidneys; however, arterioles from Sham rats responded to 1 nM Bay K 8644 while 100 nM Bay K 8644 was required to contract arterioles from diabetic rats. The EC50 for K+-induced reductions in afferent arteriolar diameter was greater in diabetic kidneys (40+/-4 mM) than in kidneys from Sham rats (28+/-4 mM; P < 0.05). In afferent arterioles isolated by microdissection from Sham rats and loaded with fura 2, increasi...Continue Reading

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Citations

Nov 24, 1999·Clinical and Experimental Pharmacology & Physiology·P K Carmines, K Ohishi
Mar 22, 2002·Clinical and Experimental Pharmacology & Physiology·Pamela K Carmines, Keiji Fujiwara
Oct 7, 2005·Journal of Hypertension·Carlos A Leon, Leopoldo Raij
Sep 23, 2009·Current Opinion in Nephrology and Hypertension·Pamela K Carmines
Oct 2, 2009·Clinical and Experimental Pharmacology & Physiology·Mitsuo MitaMasaru Shoji
Nov 13, 2004·American Journal of Physiology. Renal Physiology·Rachel W FalletPamela K Carmines
May 23, 2008·American Journal of Physiology. Renal Physiology·Carmen M Troncoso BrindeiroPamela K Carmines
Jul 17, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nobuhisa HirotaTakao Saruta
May 9, 2012·Clinical and Experimental Hypertension : CHE·Tsuneo TakenakaHiromichi Suzuki
Dec 29, 2000·Mayo Clinic Proceedings·A PfluegerF G Knox
Jul 5, 2013·Journal of Pharmacological Sciences·Raquel Gómez-PliegoRafael Villalobos-Molina
Sep 23, 2014·Mathematical Biosciences·H Frederik NijhoutMichael C Reed
Jul 29, 2005·The American Journal of Pathology·Tadeusz PawelczykAndrzej Szutowicz
Jan 25, 2018·American Journal of Physiology. Renal Physiology·Anita T Layton, Volker Vallon
Jan 13, 2005·American Journal of Physiology. Renal Physiology·Kumar SharmaEdward W Inscho
Sep 14, 2007·Pediatric Diabetes·Lorenzo PasqualiSteven Ringquist
Dec 25, 2008·American Journal of Physiology. Renal Physiology·Seiji HashimotoTakao Koike
Mar 14, 2014·American Journal of Physiology. Renal Physiology·Ioannis Sgouralis, Anita T Layton
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
Jan 23, 2015·American Journal of Physiology. Renal Physiology·Yan LuRuisheng Liu
Aug 23, 2019·American Journal of Physiology. Renal Physiology·Zhengrong GuanEdward W Inscho
Mar 10, 1999·The American Journal of Physiology·A C PfluegerF G Knox
Dec 6, 2003·American Journal of Physiology. Renal Physiology·Scott C ThomsonRoland C Blantz
Feb 9, 2000·American Journal of Physiology. Renal Physiology·G C SchoonmakerP K Carmines
Jun 30, 2018·Biological cybernetics·Anita T Layton
Jul 1, 2020·Cellular and Molecular Life Sciences : CMLS·Madeline Nieves-CintrónManuel F Navedo
Jul 24, 2003·American Journal of Physiology. Renal Physiology·Kumar SharmaGyorgy Hajnoczky
May 9, 2003·American Journal of Physiology. Renal Physiology·Radko Komers, Sharon Anderson
Sep 14, 1999·The American Journal of Physiology·A C PfluegerF G Knox
Mar 9, 2021·Future Medicinal Chemistry·Nimeet DesaiRakesh K Tekade
Nov 24, 1999·The American Journal of Physiology·A C PfluegerF G Knox
Jul 20, 2001·Journal of the American Society of Nephrology : JASN·Naohito IshiiPamela K Carmines
Jun 23, 2000·Journal of the American Society of Nephrology : JASN·Hideki IkenagaPamela K Carmines

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