Functional impairment of Tax-specific but not cytomegalovirus-specific CD8+ T lymphocytes in a minor population of asymptomatic human T-cell leukemia virus type 1-carriers

Retrovirology
Ayako TakamoriMari Kannagi

Abstract

Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a small percentage of infected individuals. ATL is often associated with general immune suppression and an impaired HTLV-1-specific T-cell response, an important host defense system. We previously found that a small fraction of asymptomatic HTLV-1-carriers (AC) already showed impaired T-cell responses against the major target antigen, Tax. However, it is unclear whether the impaired HTLV-1 Tax-specific T-cell response in these individuals is an HTLV-1-specific phenomenon, or merely reflects general immune suppression. In this study, in order to characterize the impaired HTLV-1-specific T-cell response, we investigated the function of Tax-specific CD8+ T-cells in various clinical status of HTLV-1 infection. By using tetramers consisting of HLA-A*0201, -A*2402, or -A*1101, and corresponding Tax epitope peptides, we detected Tax-specific CD8+ T-cells in the peripheral blood from 87.0% of ACs (n = 20/23) and 100% of HAM/TSP patients (n = 18/18) tested. We also detected Tax-specific CD8+ T-cells in 38.1% of chronic type ATL (cATL) patients (n = 8/21), although its frequencies in pe...Continue Reading

References

Jul 12, 1986·Lancet·M OsameY Shibata
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·Y HinumaI Miyoshi
May 1, 1993·AIDS Research and Human Retroviruses·G de Thé, R Bomford
Jan 1, 1997·Annual Review of Immunology·T Uchiyama
Dec 22, 1998·The Journal of Experimental Medicine·Allan J ZajacRafi Ahmed
Mar 10, 2001·Nature·P ChampagneG Pantaleo
May 18, 2001·Journal of Virology·Norbert GruenerPaul Klenerman
Apr 3, 2002·Nature Medicine·Victor AppaySarah L Rowland-Jones
Dec 4, 2003·Nature Reviews. Immunology·René A W van LierLaila E Gamadia
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·E John WherryRafi Ahmed
Aug 24, 2005·Nature Immunology·Paul Klenerman, Ann Hill
Dec 20, 2005·International Immunology·Shuming ChenKazuo Sugamura
Jun 3, 2006·Journal of Neuroimmunology·Julie M Johnson-NaurothPeter A Calabresi
Jul 11, 2006·Immunological Reviews·Christopher A KlebanoffNicholas P Restifo
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Amalia PennaCarlo Ferrari
Sep 10, 2008·Blood·Charles R M Bangham
Mar 6, 2010·Immunology·John S YiAllan J Zajac

Citations

Dec 21, 2012·Retrovirology·Kuan-Teh Jeang
Oct 4, 2014·Biochemical and Biophysical Research Communications·Chioma Ezinne ChibuezeNaomichi Arima
Aug 15, 2014·Biochimica Et Biophysica Acta·M Lienhard SchmitzVera V Saul
Dec 25, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Satomi AndoMari Kannagi
Mar 12, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yotaro TamaiMari Kannagi
Mar 3, 2020·Frontiers in Microbiology·Kunihiko Umekita, Akihiko Okayama
Sep 29, 2018·Annals of Hematology·Hiroshi UreshinoShinya Kimura
Jul 11, 2020·Pathogens·Suchitra Mohanty, Edward W Harhaj

Methods Mentioned

BETA
flow cytometry
ELISA
FACS

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