Functional implications of myocardial scar structure

The American Journal of Physiology
J W HolmesJames W Covell

Abstract

During healing after myocardial infarction, scar collagen content and stiffness do not correlate. We studied regional mechanics and both area fraction and orientation of large collagen fibers 3 wk after coronary ligation in the pig. During passive inflation of isolated, arrested hearts, the scar tissue demonstrated significantly less circumferential strain but similar longitudinal and radial deformation in comparison with noninfarcted regions of the same hearts. The observed selective resistance to circumferential deformation was consistent with the finding that most of the large collagen fibers in the scar were oriented within 30 degrees of the local circumferential axis. Furthermore, data from a previous study indicate that during ventricular systole these scars resist circumferential stretching, whereas they deform similarly to noninfarcted myocardium in the longitudinal and radial directions. We conclude that large collagen fiber structure is an important determinant of scar mechanical properties and that scar anisotropy allows the scar to resist circumferential stretching while deforming compatibly with adjacent noninfarcted myocardium in the longitudinal and radial directions.

Citations

Jul 12, 2005·Annual Review of Biomedical Engineering·Jeffrey W HolmesJames W Covell
Nov 10, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Gregory M Fomovsky, Jeffrey W Holmes
May 17, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Darren H FreedIan M C Dixon
Mar 25, 2011·Journal of Biomechanical Engineering·Jonathan F WenkJulius M Guccione
Apr 9, 2019·Journal of Biomechanical Engineering·Jeffrey W Holmes
May 30, 2019·Journal of Biomechanical Engineering·Christopher E KorenczukWilliam J Richardson
Apr 13, 2012·The Journal of Physiology·Andrew D Rouillard, Jeffrey W Holmes
Feb 10, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Halvor K MørkWilliam E Louch
Jun 6, 2012·Circulation. Heart Failure·Gregory M FomovskyJeffrey W Holmes
Jan 25, 2014·Theoretical Biology & Medical Modelling·Andrew P Voorhees, Hai-Chao Han
Jul 15, 2016·Annals of Biomedical Engineering·Eva RomitoFrancis G Spinale
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J HaoI M Dixon
Jan 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S D ZimmermanJ W Covell
May 24, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Hiroshi AshikagaElliot R McVeigh
Feb 27, 2017·Journal of Applied Physiology·Eva RomitoFrancis G Spinale
Nov 23, 2010·Journal of Cardiovascular Translational Research·Gregory M FomovskyJeffrey W Holmes
Apr 28, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Thomas Helle-ValleOtto A Smiseth
Feb 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Wenguang Li
Jan 31, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Bryn L BrazileJun Liao

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