Functional implications of seizure-induced neurogenesis

Advances in Experimental Medicine and Biology
Helen E Scharfman

Abstract

The neurobiological doctrine governing the concept of neurogenesis has undergone a revolution in the past few years. What was once considered dubious is now well accepted: new neurons are born in the adult brain. Science fiction is quickly becoming a reality as scientists discover ways to convert skin, bone, or blood cells into neurons. In the epilepsy arena, widespread interest has developed because of the evidence that neurogenesis increases after seizures, trauma, and other insults or injuries that alter seizure susceptibility. This review discusses some of the initial studies in this field, and their often surprising functional implications. The emphasis will be on the granule cells of hippocampus, because they are perhaps more relevant to epilepsy than other areas in which neurogenesis occurs throughout life, the olfactory bulb and subventricular zone. In particular, the following questions will be addressed: 1. Do granule cells that are born in the adult brain become functional, and what are the limits of their function? Do they behave homogeneously? Results from our own laboratory have focused on cells that become established outside the normal boundaries of the granule cell layer, forming a group of "ectopic" granule ce...Continue Reading

Citations

Mar 8, 2006·The European Journal of Neuroscience·Sara BondeOlle Lindvall
Sep 8, 2005·Epilepsy Currents·Helen E Scharfman
Dec 7, 2006·Developmental Neuroscience·H Jurgen WenzelPhilip A Schwartzkroin
Dec 13, 2006·The European Journal of Neuroscience·Paul D SmithMark J Cook
Aug 19, 2007·Journal of Neurochemistry·Hideyuki OkanoKazunobu Sawamoto
Dec 5, 2008·Epilepsia·Marian Joëls
Jun 29, 2017·Brain Structure & Function·Alejandra Magagna-PovedaHelen E Scharfman
Jun 25, 2019·Epilepsy Currents·Helen E Scharfman
Feb 24, 2011·The Journal of Comparative Neurology·Joseph P PierceHelen E Scharfman
Sep 3, 2011·Neuropathology and Applied Neurobiology·E-L von RüdenH Potschka
May 5, 2017·Nature Reviews. Neuroscience·Christoph Anacker, René Hen
Aug 5, 2010·Hippocampus·Catherine E Myers, Helen E Scharfman
Sep 9, 2015·Frontiers in Systems Neuroscience·Helen E Scharfman, Hannah L Bernstein
Jan 1, 2015·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N V Gulyaeva
Jan 19, 2017·Reviews in the Neurosciences·Mojdeh NavidhamidiNasrin Mehranfard
Dec 7, 2006·Developmental Neuroscience·Helen ScharfmanDaniel McCloskey
Apr 17, 2009·Epilepsy Research·Helen E Scharfman, Daniel P McCloskey
Jan 20, 2007·Science·Helen E Scharfman, Rene Hen

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