Functional implications of sexual dimorphism of transporter patterns along the rat proximal tubule: modeling and analysis

American Journal of Physiology. Renal Physiology
Qianyi LiAnita T Layton

Abstract

The goal of this study is to investigate the functional implications of the sexual dimorphism in transporter patterns along the proximal tubule. To do so, we have developed sex-specific computational models of solute and water transport in the proximal convoluted tubule of the rat kidney. The models account for the sex differences in expression levels of the apical and basolateral transporters, in single-nephron glomerular filtration rate, and in tubular dimensions. Model simulations predict that 70.6 and 38.7% of the filtered volume is reabsorbed by the proximal tubule of the male and female rat kidneys, respectively. The lower fractional volume reabsorption in females can be attributed to their smaller transport area and lower aquaporin-1 expression level. The latter also results in a larger contribution of the paracellular pathway to water transport. Correspondingly similar fractions (70.9 and 39.2%) of the filtered Na+ are reabsorbed by the male and female proximal tubule models, respectively. The lower fractional Na+ reabsorption in females is due primarily to their smaller transport area and lower Na+/H+ exchanger isoform 3 and claudin-2 expression levels. Notably, unlike most Na+ transporters, whose expression levels are...Continue Reading

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Citations

Dec 6, 2018·American Journal of Physiology. Renal Physiology·Anita T Layton
Dec 20, 2018·American Journal of Physiology. Renal Physiology·Anita T Layton, Jennifer C Sullivan
Nov 30, 2018·American Journal of Physiology. Renal Physiology·Blythe D ShepardJennifer L Pluznick
Feb 14, 2019·American Journal of Physiology. Renal Physiology·Michael J Ryan, Jennifer C Sullivan
Mar 16, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Sameed AhmedAnita T Layton
Feb 11, 2020·American Journal of Physiology. Renal Physiology·Sameed Ahmed, Anita T Layton
Aug 4, 2020·American Journal of Physiology. Renal Physiology·Rui HuAnita T Layton
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Jun 27, 2019·American Journal of Physiology. Renal Physiology·Blythe D Shepard
Oct 1, 2019·American Journal of Physiology. Renal Physiology·Rui HuAnita T Layton
May 22, 2020·Frontiers in Pharmacology·Jacklean KalibalaJules Desmeules
Feb 21, 2019·American Journal of Physiology. Renal Physiology·Aurélie EdwardsOlivier Bonny
Sep 15, 2020·American Journal of Physiology. Renal Physiology·Ebrahim TahaeiPaul A Welling
Dec 15, 2020·American Journal of Physiology. Renal Physiology·Autumn N Harris, I David Weiner
Nov 26, 2018·Computers in Biology and Medicine·Jessica Leete, Anita T Layton
Mar 27, 2021·Journal of the American Society of Nephrology : JASN·Lihe ChenMark A Knepper
Apr 1, 2021·PLoS Computational Biology·Stéphanie M C Abo, Anita T Layton
May 7, 2021·Advanced Drug Delivery Reviews·Shahriar SharifiMorteza Mahmoudi
Jun 3, 2021·International Journal of Molecular Sciences·Rui Hu, Anita Layton
Jun 14, 2021·Mathematical Biosciences·Anita T Layton
Jul 3, 2021·Viruses·Mehrshad Sadria, Anita T Layton
Jul 1, 2021·American Journal of Physiology. Cell Physiology·Spencer LewisMark A Knepper
Oct 5, 2021·American Journal of Physiology. Renal Physiology·Autumn N HarrisI David Weiner
Oct 7, 2021·American Journal of Physiology. Cell Physiology·Diana L Torres-PinzonAlicia A McDonough

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