Functional improvement in a patient with cerebral calcinosis using a bisphosphonate

Movement Disorders : Official Journal of the Movement Disorder Society
Jeffrey A Loeb

Abstract

Idiopathic cerebral calcification can be associated with a progressive neurologic disorder for which there is no known treatment. This report describes a patient with a familial form of this disorder presenting in middle age with progressive Parkinson-like features along with spasticity, dystonia, and ataxia. Disodium etidronate, a bisphosphonate, produced a two-fold improvement in the rate of his speech and gait, but did not affect his spasticity, dystonia, or ataxia. Quantitative analysis of cerebral calcification did not reveal any reduction in the amount of calcification, suggesting other possible mechanisms for this clinical improvement.

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Citations

Apr 11, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·B V ManyamK R Narla
Sep 29, 2000·Parkinsonism & Related Disorders·J E Ahlskog
Aug 25, 2009·Parkinsonism & Related Disorders·Alon AbrahamRuth Djaldetti
Mar 10, 2016·BMC Neurology·Chih-Sheng YangMan-Chun Wu
Mar 1, 2005·Parkinsonism & Related Disorders·Bala V Manyam
Jan 25, 2006·Journal of the Neurological Sciences·Jeffrey A LoebDarren R Fuerst
Nov 7, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Nigel D ToussaintPeter G Kerr
Jul 4, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Giulia DonzusoMario Zappia
Jun 18, 2019·Pharmacological Reports : PR·Sara Hadj Sadok, João Ricardo Mendes de Oliveira
Jun 7, 2017·Current Osteoporosis Reports·Yvonne Nitschke, Frank Rutsch
Jun 25, 2017·Inflammopharmacology·Paola Maura TricaricoSergio Crovella

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