Functional improvement in chronic human spinal cord injury: Four years after acidic fibroblast growth factor

Scientific Reports
Chin-Chu KoHenrich Cheng

Abstract

Few treatments have proven effective for patients with chronic spinal cord injury (SCI). This study aimed to evaluate the efficacy and safety of acidic fibroblast growth factor (aFGF) in human SCI. This was an open-label prospective clinical trial of aFGF with an extended follow-up to 48 months. All patients were treated with aFGF 3 times, including once directly applied to the injured spinal cord during neurolysis surgery, and twice via lumbar punctures at 3- and 6-months post-operation. Every patient was evaluated with standardized measurements of neurological functions. The trial initially enrolled 60 patients (30 cervical and 30 thoracolumbar SCI), but only 46 (21 cervical- and 25 thoracolumbar-SCI) completed the follow-up. The ASIA impairment scales, motor, pin prick, light touch, and FIM motor subtotal scores were all improved in both groups, except that the ASIA scores of light touch only demonstrated tendency of increase in the cervical-SCI group. All patients had a decrease in dependence, and there were no major adverse events or other oncological problems throughout the follow-up. At 48 months, the study demonstrated that aFGF was safe, feasible, and could yield modest functional improvement in chronic SCI patients. F...Continue Reading

References

Aug 1, 1989·The Journal of Cell Biology·P L McNeilP A D'Amore
Jan 1, 1995·Journal of Neural Transplantation & Plasticity·H ChengL Olson
Jan 24, 1998·Experimental Neurology·H ChengL Olson
Nov 24, 1999·Archives of Physical Medicine and Rehabilitation·K M HallP Werner
Nov 13, 2002·Journal of Neurotrauma·Yu-Shang LeeVernon W Lin
Apr 10, 2003·Experimental Neurology·Ming-Chao HuangHenrich Cheng
Aug 11, 2004·Injury·Sanford P C HsuHenrich Cheng
Nov 3, 2004·Archives of Physical Medicine and Rehabilitation·Steven KirshblumDavid Tulsky
Sep 6, 2005·Journal of the Chinese Medical Association : JCMA·Pei-Hsin LinTien-Yow Chuang
Feb 21, 2006·The European Journal of Neuroscience·Yu-Shang LeeVernon W Lin
Jun 25, 2009·Journal of Neurotrauma·Ming-Chao HuangHenrich Cheng
Jun 15, 2011·Journal of Neurosurgery. Spine·Jau-Ching WuHenrich Cheng
Mar 8, 2018·Journal of Cellular and Molecular Medicine·Jiawei LiFanghua Gong

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Citations

Jan 18, 2019·Neurospine·Chin-Chu KoHenrich Cheng
Aug 11, 2020·Journal of Biological Engineering·Ziyuan YuZhiping Qi
Jan 8, 2020·Journal of Orthopaedic Translation·Hongyun HuangUNKNOWN International Association of Neurorestoratology and The Chinese Association of Neurorestoratology
Aug 8, 2021·International Journal of Molecular Sciences·Li-Yu FayHenrich Cheng

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Methods Mentioned

BETA
electrophoresis

Clinical Trials Mentioned

NCT03229031

Software Mentioned

Statplus

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